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Page 1
Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change.
Dehkordi SR, Wong IT, Ni J, Luebeck J, Zhu K, Prasad G, Krockenberger L, Xu G, Chowdhury B, Rajkumar U, Caplin A, Muliaditan D, Coruh C, Jin Q, Turner K, Teo SX, Pang AWC, Alexandrov LB, Chua CEL, Furnari FB, Paulson TG, Law JA, Chang HY, Yue F, DasGupta R, Zhao J, Mischel PS, Bafna V. Dehkordi SR, et al. Among authors: law ja. bioRxiv [Preprint]. 2023 Dec 13:2023.12.12.571349. doi: 10.1101/2023.12.12.571349. bioRxiv. 2023. PMID: 38168210 Free PMC article. Preprint.
Circular ecDNA promotes accessible chromatin and high oncogene expression.
Wu S, Turner KM, Nguyen N, Raviram R, Erb M, Santini J, Luebeck J, Rajkumar U, Diao Y, Li B, Zhang W, Jameson N, Corces MR, Granja JM, Chen X, Coruh C, Abnousi A, Houston J, Ye Z, Hu R, Yu M, Kim H, Law JA, Verhaak RGW, Hu M, Furnari FB, Chang HY, Ren B, Bafna V, Mischel PS. Wu S, et al. Among authors: law ja. Nature. 2019 Nov;575(7784):699-703. doi: 10.1038/s41586-019-1763-5. Epub 2019 Nov 20. Nature. 2019. PMID: 31748743 Free PMC article.
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH.
Hung KL, Luebeck J, Dehkordi SR, Colón CI, Li R, Wong IT, Coruh C, Dharanipragada P, Lomeli SH, Weiser NE, Moriceau G, Zhang X, Bailey C, Houlahan KE, Yang W, González RC, Swanton C, Curtis C, Jamal-Hanjani M, Henssen AG, Law JA, Greenleaf WJ, Lo RS, Mischel PS, Bafna V, Chang HY. Hung KL, et al. Among authors: law ja. Nat Genet. 2022 Nov;54(11):1746-1754. doi: 10.1038/s41588-022-01190-0. Epub 2022 Oct 17. Nat Genet. 2022. PMID: 36253572 Free PMC article.
CLSY docking to Pol IV requires a conserved domain critical for small RNA biogenesis and transposon silencing.
Felgines L, Rymen B, Martins LM, Xu G, Matteoli C, Himber C, Zhou M, Eis J, Coruh C, Böhrer M, Kuhn L, Chicher J, Pandey V, Hammann P, Wohlschlegel J, Waltz F, Law JA, Blevins T. Felgines L, et al. Among authors: law ja. bioRxiv [Preprint]. 2023 Dec 26:2023.12.26.573199. doi: 10.1101/2023.12.26.573199. bioRxiv. 2023. Update in: Nat Commun. 2024 Nov 27;15(1):10298. doi: 10.1038/s41467-024-54268-0 PMID: 38234754 Free PMC article. Updated. Preprint.
A single-nuclei transcriptome census of the Arabidopsis maturing root identifies that MYB67 controls phellem cell maturation.
Miller CN, Jarrell-Hurtado S, Haag MV, Sara Ye Y, Simenc M, Alvarez-Maldonado P, Behnami S, Zhang L, Swift J, Papikian A, Yu J, Colt K, Ecker JR, Michael TP, Law JA, Busch W. Miller CN, et al. Among authors: law ja. Dev Cell. 2025 Jan 6:S1534-5807(24)00764-0. doi: 10.1016/j.devcel.2024.12.025. Online ahead of print. Dev Cell. 2025. PMID: 39793584
97 results