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Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus.
Phelps GA, Cheramie MN, Fernando DM, Selchow P, Meyer CJ, Waidyarachchi SL, Dharuman S, Liu J, Meuli M, Molin MD, Killam BY, Murphy PA, Reeve SM, Wilt LA, Anderson SM, Yang L, Lee RB, Temrikar ZH, Lukka PB, Meibohm B, Polikanov YS, Hobbie SN, Böttger EC, Sander P, Lee RE. Phelps GA, et al. Among authors: yang l. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2314101120. doi: 10.1073/pnas.2314101120. Epub 2024 Jan 2. Proc Natl Acad Sci U S A. 2024. PMID: 38165935 Free PMC article.
Development of Brain Penetrant Pyridazine Pantothenate Kinase Activators.
Tangallapally R, Subramanian C, Yun MK, Edwards A, Sharma LK, Yang L, Creed K, Wang J, Jackowski S, Rock CO, White SW, Lee RE. Tangallapally R, et al. Among authors: yang l. J Med Chem. 2024 Aug 22;67(16):14432-14442. doi: 10.1021/acs.jmedchem.4c01211. Epub 2024 Aug 13. J Med Chem. 2024. PMID: 39136313 Free PMC article.
Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.
Scott DC, Dharuman S, Griffith E, Chai SC, Ronnebaum J, King MT, Tangallapally R, Lee C, Gee CT, Yang L, Li Y, Loudon VC, Lee HW, Ochoada J, Miller DJ, Jayasinghe T, Paulo JA, Elledge SJ, Harper JW, Chen T, Lee RE, Schulman BA. Scott DC, et al. Among authors: yang l. Nat Commun. 2024 Oct 12;15(1):8829. doi: 10.1038/s41467-024-52966-3. Nat Commun. 2024. PMID: 39396041 Free PMC article.
Antitrypanosomal Chloronitrobenzamides.
Carrillo AK, Kadayat TM, Hwang JY, Chen Y, Zhu F, Holbrook G, Gillingwater K, Connelly MC, Yang L, Kaiser M, Guy RK. Carrillo AK, et al. Among authors: yang l. J Med Chem. 2024 Mar 14;67(5):3437-3447. doi: 10.1021/acs.jmedchem.3c01680. Epub 2024 Feb 16. J Med Chem. 2024. PMID: 38363074
Preclinical evaluation of proteolytic targeting of LCK as a therapeutic approach in T cell acute lymphoblastic leukemia.
Hu J, Jarusiewicz J, Du G, Nishiguchi G, Yoshimura S, Panetta JC, Li Z, Min J, Yang L, Chepyala D, Actis M, Reyes N, Smart B, Pui CH, Teachey DT, Rankovic Z, Yang JJ. Hu J, et al. Among authors: yang l, yang jj. Sci Transl Med. 2022 Aug 24;14(659):eabo5228. doi: 10.1126/scitranslmed.abo5228. Epub 2022 Aug 24. Sci Transl Med. 2022. PMID: 36001679 Free PMC article.
Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy.
Zuckermann M, He C, Andrews J, Bagchi A, Sloan-Henry R, Bianski B, Xie J, Wang Y, Twarog N, Onar-Thomas A, Ernst KJ, Yang L, Li Y, Zhu X, Ocasio JK, Budd KM, Dalton J, Li X, Chepyala D, Zhang J, Xu K, Hover L, Roach JT, Chan KC, Hofmann N, McKinnon PJ, Pfister SM, Shelat AA, Rankovic Z, Freeman BB 3rd, Chiang J, Jones DTW, Tinkle CL, Baker SJ. Zuckermann M, et al. Among authors: yang l. Mol Cancer. 2024 Jun 7;23(1):123. doi: 10.1186/s12943-024-02027-6. Mol Cancer. 2024. PMID: 38849845 Free PMC article.
Development of an Orally Bioavailable LCK PROTAC Degrader as a Potential Therapeutic Approach to T-Cell Acute Lymphoblastic Leukemia.
Jarusiewicz JA, Yoshimura S, Actis M, Li Y, Fu X, Yang L, Narina S, Pruett-Miller SM, Zhou S, Wang X, High AA, Nishiguchi G, Yang JJ, Rankovic Z. Jarusiewicz JA, et al. Among authors: yang l, yang jj. J Med Chem. 2024 Jul 25;67(14):11868-11884. doi: 10.1021/acs.jmedchem.4c00481. Epub 2024 Jul 8. J Med Chem. 2024. PMID: 38973320
57,263 results
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