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Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus.
Phelps GA, Cheramie MN, Fernando DM, Selchow P, Meyer CJ, Waidyarachchi SL, Dharuman S, Liu J, Meuli M, Molin MD, Killam BY, Murphy PA, Reeve SM, Wilt LA, Anderson SM, Yang L, Lee RB, Temrikar ZH, Lukka PB, Meibohm B, Polikanov YS, Hobbie SN, Böttger EC, Sander P, Lee RE. Phelps GA, et al. Among authors: liu j. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2314101120. doi: 10.1073/pnas.2314101120. Epub 2024 Jan 2. Proc Natl Acad Sci U S A. 2024. PMID: 38165935 Free PMC article.
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.
Lee RE, Hurdle JG, Liu J, Bruhn DF, Matt T, Scherman MS, Vaddady PK, Zheng Z, Qi J, Akbergenov R, Das S, Madhura DB, Rathi C, Trivedi A, Villellas C, Lee RB, Rakesh, Waidyarachchi SL, Sun D, McNeil MR, Ainsa JA, Boshoff HI, Gonzalez-Juarrero M, Meibohm B, Böttger EC, Lenaerts AJ. Lee RE, et al. Among authors: liu j. Nat Med. 2014 Feb;20(2):152-158. doi: 10.1038/nm.3458. Epub 2014 Jan 26. Nat Med. 2014. PMID: 24464186 Free PMC article.
Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections.
Bruhn DF, Waidyarachchi SL, Madhura DB, Shcherbakov D, Zheng Z, Liu J, Abdelrahman YM, Singh AP, Duscha S, Rathi C, Lee RB, Belland RJ, Meibohm B, Rosch JW, Böttger EC, Lee RE. Bruhn DF, et al. Among authors: liu j. Sci Transl Med. 2015 May 20;7(288):288ra75. doi: 10.1126/scitranslmed.3010572. Sci Transl Med. 2015. PMID: 25995221 Free PMC article.
Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids.
Rakesh, Bruhn DF, Scherman MS, Singh AP, Yang L, Liu J, Lenaerts AJ, Lee RE. Rakesh, et al. Among authors: liu j. Bioorg Med Chem Lett. 2016 Jan 15;26(2):388-391. doi: 10.1016/j.bmcl.2015.12.002. Epub 2015 Dec 7. Bioorg Med Chem Lett. 2016. PMID: 26711150 Free PMC article.
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