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XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer.
Jenkins KA, Park M, Pederzoli-Ribeil M, Eskiocak U, Johnson P, Guzman W, McLaughlin M, Moore-Lai D, O'Toole C, Liu Z, Nicholson B, Flesch V, Qiu H, Clackson T, O'Hagan RC, Rodeck U, Karow M, O'Neil J, Williams JC. Jenkins KA, et al. Among authors: mclaughlin m. J Immunother Cancer. 2023 Dec 12;11(12):e007785. doi: 10.1136/jitc-2023-007785. J Immunother Cancer. 2023. PMID: 38164757 Free PMC article.
XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies.
Patel E, Malkova NV, Crowe D, Pederzoli-Ribeil M, Fantini D, Fanny M, Madala HR, Jenkins KA, Yerov O, Greene J, Guzman W, O'Toole C, Taylor J, O'Donnell RK, Johnson P, Lanter BB, Ames B, Chen J, Vu S, Wu HJ, Cantin S, McLaughlin M, Hsiao YS, Tomar DS, Rozenfeld R, Thiruneelakantapillai L, O'Hagan RC, Nicholson B, O'Neil J, Bialucha CU. Patel E, et al. Among authors: mclaughlin m. Mol Cancer Ther. 2024 Apr 2;23(4):421-435. doi: 10.1158/1535-7163.MCT-23-0336. Mol Cancer Ther. 2024. PMID: 38030380 Free PMC article.
A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor-specificity.
Synan A, Wu NC, Velazquez R, Gesner T, Logel C, Mueller K, Green A, Barzaghi-Rinaudo P, Simmons Q, Mercan S, Shi X, Li X, Sagar V, Korn J, McLaughlin M, Tschantz WR, Hainzl D, Malamas A, Huber T, Cebe R, Xie KT, D'Alessio JA. Synan A, et al. Among authors: mclaughlin m. MAbs. 2025 Dec;17(1):2441411. doi: 10.1080/19420862.2024.2441411. Epub 2025 Jan 6. MAbs. 2025. PMID: 39762718 Free article.
CXCL12-targeted immunomodulatory gene therapy reduces radiation-induced fibrosis in healthy tissues.
Paget JT, Ward JA, McKean AR, Mansfield DC, McLaughlin M, Kyula-Currie JN, Smith HG, Roulstone V, Li C, Zhou Y, Hardiman T, Grigoriadis A, O'Brien Coon D, Irshad S, Melcher AA, Harrington KJ, Khan A. Paget JT, et al. Among authors: mclaughlin m. Mol Cancer Ther. 2024 Dec 12. doi: 10.1158/1535-7163.MCT-23-0872. Online ahead of print. Mol Cancer Ther. 2024. PMID: 39666014
Discovery and engineering of the antibody response to a prominent skin commensal.
Bousbaine D, Bauman KD, Chen YE, Lalgudi PV, Nguyen TTD, Swenson JM, Yu VK, Tsang E, Conlan S, Li DB, Jbara A, Zhao A, Naziripour A, Veinbachs A, Lee YE, Phung JL, Dimas A, Jain S, Meng X, Pham TPT, McLaughlin MI, Barkal LJ, Gribonika I, Van Rompay KKA, Kong HH, Segre JA, Belkaid Y, Barnes CO, Fischbach MA. Bousbaine D, et al. Among authors: mclaughlin mi. Nature. 2024 Dec 11. doi: 10.1038/s41586-024-08489-4. Online ahead of print. Nature. 2024. PMID: 39662508
Managing non-traumatic musculoskeletal conditions presenting to emergency departments: Do patient profiles vary between a physiotherapy-led 'Diversion' pathway and routine care?
Waller R, McLaughlin M, King S, Lai J, Holt R, Flanagan P, Lin I, Richards K, Truter P. Waller R, et al. Among authors: mclaughlin m. Australas Emerg Care. 2024 Nov 20:S2588-994X(24)00051-4. doi: 10.1016/j.auec.2024.08.001. Online ahead of print. Australas Emerg Care. 2024. PMID: 39572324 Free article.
1,552 results