Gruenhagen JA - Search Results

1

Automated online deconjugation of antibody-drug conjugate for small molecule drug profiling.

Thomas R, Song D, Pourmohamad T, Kurita K, Chin S, Dai L, Goyon A, Medley CD, Gruenhagen JA, Chen T. Thomas R, et al. Among authors: gruenhagen ja. J Chromatogr A. 2024 Jan 25;1715:464575. doi: 10.1016/j.chroma.2023.464575. Epub 2023 Dec 17. J Chromatogr A. 2024. PMID: 38150875

2

Quantification of residual solvents in antibody drug conjugates using gas chromatography.

Medley CD, Kay J, Li Y, Gruenhagen J, Yehl P, Chetwyn NP. Medley CD, et al. Anal Chim Acta. 2014 Nov 19;850:92-6. doi: 10.1016/j.aca.2014.09.003. Epub 2014 Sep 8. Anal Chim Acta. 2014. PMID: 25441165

3

A size exclusion-reversed phase two dimensional-liquid chromatography methodology for stability and small molecule related species in antibody drug conjugates.

Li Y, Gu C, Gruenhagen J, Zhang K, Yehl P, Chetwyn NP, Medley CD. Li Y, et al. J Chromatogr A. 2015 May 8;1393:81-8. doi: 10.1016/j.chroma.2015.03.027. Epub 2015 Mar 16. J Chromatogr A. 2015. PMID: 25818558

4

Chemical de-conjugation for investigating the stability of small molecule drugs in antibody-drug conjugates.

Chen T, Su D, Gruenhagen J, Gu C, Li Y, Yehl P, Chetwyn NP, Medley CD. Chen T, et al. J Pharm Biomed Anal. 2016 Jan 5;117:304-10. doi: 10.1016/j.jpba.2015.09.015. Epub 2015 Sep 15. J Pharm Biomed Anal. 2016. PMID: 26406314

5

An enzymatic deconjugation method for the analysis of small molecule active drugs on antibody-drug conjugates.

Li Y, Gu C, Gruenhagen J, Yehl P, Chetwyn NP, Medley CD. Li Y, et al. MAbs. 2016 May-Jun;8(4):698-705. doi: 10.1080/19420862.2016.1151590. Epub 2016 Feb 18. MAbs. 2016. PMID: 26891281 Free PMC article.

6

Investigation of low recovery in the free drug assay for antibody drug conjugates by size exclusion-reversed phase two dimensional-liquid chromatography.

Li Y, Stella C, Zheng L, Bechtel C, Gruenhagen J, Jacobson F, Medley CD. Li Y, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 1;1032:112-118. doi: 10.1016/j.jchromb.2016.05.011. Epub 2016 May 10. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 27212187

7

Antibody-drug conjugate characterization by chromatographic and electrophoretic techniques.

Chen T, Chen Y, Stella C, Medley CD, Gruenhagen JA, Zhang K. Chen T, et al. Among authors: gruenhagen ja. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 1;1032:39-50. doi: 10.1016/j.jchromb.2016.07.023. Epub 2016 Jul 14. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 27451254 Review.

8

Impact of polymer type, ASD loading and polymer-drug ratio on ASD tablet disintegration and drug release.

Zhang W, Noland R, Chin S, Petkovic M, Zuniga R, Santarra B, Conklin B, Hou HH, Nagapudi K, Gruenhagen JA, Yehl P, Chen T. Zhang W, et al. Among authors: gruenhagen ja. Int J Pharm. 2021 Jan 5;592:120087. doi: 10.1016/j.ijpharm.2020.120087. Epub 2020 Nov 12. Int J Pharm. 2021. PMID: 33189812

9

Simultaneous quantitation of water and residual solvents in pharmaceuticals by rapid headspace gas chromatography with thermal conductivity detection (GC-TCD).

Kay J, Thomas R, Gruenhagen J, Venkatramani CJ. Kay J, et al. J Pharm Biomed Anal. 2021 Feb 5;194:113796. doi: 10.1016/j.jpba.2020.113796. Epub 2020 Nov 25. J Pharm Biomed Anal. 2021. PMID: 33288344

10

Multiplexed small molecule impurity monitoring in antibody-based therapeutics by mixed-mode chromatography paired with charged aerosol detection.

Chin S, Lin XX, Santarra B, Gruenhagen JA, Yehl P, Chen T. Chin S, et al. Among authors: gruenhagen ja. J Pharm Biomed Anal. 2021 Apr 15;197:113952. doi: 10.1016/j.jpba.2021.113952. Epub 2021 Feb 4. J Pharm Biomed Anal. 2021. PMID: 33601156

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