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Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain.
Geurs S, Staessens E, Bredael K, Borghgraef S, De Ridder J, Persoons L, De Jonghe S, Schols D, Mann MK, Harding RJ, Franceus J, Desmet T, Van Hecke K, Clarisse D, De Bosscher K, D'hooghe M. Geurs S, et al. Among authors: de jonghe s. Eur J Med Chem. 2025 Mar 5;285:117208. doi: 10.1016/j.ejmech.2024.117208. Epub 2024 Dec 27. Eur J Med Chem. 2025. PMID: 39823806
Discovery of (3-Phenylcarbamoyl-3,4-dihydro-2H-pyrrol-2-yl)phosphonates as Imidazoline I2 Receptor Ligands with Anti-Alzheimer and Analgesic Properties.
Bagán A, López-Ruiz A, Abás S, Ruiz-Cantero MC, Vasilopoulou F, Taboada-Jara T, Griñán-Ferré C, Pallàs M, Muguruza C, Diez-Alarcia R, Callado LF, Entrena JM, Cobos EJ, Pérez B, Morales-García JA, Molins E, De Jonghe S, Daelemans D, Brea J, Val C, Loza MI, Hernández-Hernández E, García-Sevilla JA, García-Fuster MJ, Díaz C, Fernández-Godino R, Genilloud O, Beljkaš M, Oljačić S, Nikolic K, Escolano C. Bagán A, et al. Among authors: de jonghe s. J Med Chem. 2025 Jan 17. doi: 10.1021/acs.jmedchem.4c01644. Online ahead of print. J Med Chem. 2025. PMID: 39818939
3-nitropyridine analogues as novel microtubule-targeting agents.
Herman J, Vanstreels E, Bardiot D, Prota AE, Gaillard N, Gao LJ, Vercruysse T, Persoons L, Daems T, Waer M, Herdewijn P, Louat T, Steinmetz MO, De Jonghe S, Sprangers B, Daelemans D. Herman J, et al. Among authors: de jonghe s. PLoS One. 2024 Nov 7;19(11):e0307153. doi: 10.1371/journal.pone.0307153. eCollection 2024. PLoS One. 2024. PMID: 39509402 Free PMC article.
157 results