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Genome-scale exon perturbation screens uncover exons critical for cell fitness.
Xiao MS, Damodaran AP, Kumari B, Dickson E, Xing K, On TA, Parab N, King HE, Perez AR, Guiblet WM, Duncan G, Che A, Chari R, Andresson T, Vidigal JA, Weatheritt RJ, Aregger M, Gonatopoulos-Pournatzis T. Xiao MS, et al. Among authors: aregger m. Mol Cell. 2024 Jul 11;84(13):2553-2572.e19. doi: 10.1016/j.molcel.2024.05.024. Epub 2024 Jun 24. Mol Cell. 2024. PMID: 38917794 Free article.
Reproducibility metrics for context-specific CRISPR screens.
Billmann M, Ward HN, Aregger M, Costanzo M, Andrews BJ, Boone C, Moffat J, Myers CL. Billmann M, et al. Among authors: aregger m. Cell Syst. 2023 May 17;14(5):418-422.e2. doi: 10.1016/j.cels.2023.04.003. Cell Syst. 2023. PMID: 37201508 Free PMC article.
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux.
Masud SN, Chandrashekhar M, Aregger M, Tan G, Zhang X, Mero P, Pirman DA, Zaslaver O, Smolen GA, Lin ZY, Wong CJ, Boone C, Gingras AC, Montenegro-Burke JR, Moffat J. Masud SN, et al. Among authors: aregger m. Nat Chem Biol. 2022 Dec;18(12):1370-1379. doi: 10.1038/s41589-022-01109-0. Epub 2022 Aug 15. Nat Chem Biol. 2022. PMID: 35970996
Analysis of combinatorial CRISPR screens with the Orthrus scoring pipeline.
Ward HN, Aregger M, Gonatopoulos-Pournatzis T, Billmann M, Ohsumi TK, Brown KR, Blencowe BJ, Moffat J, Myers CL. Ward HN, et al. Among authors: aregger m. Nat Protoc. 2021 Oct;16(10):4766-4798. doi: 10.1038/s41596-021-00596-0. Epub 2021 Sep 10. Nat Protoc. 2021. PMID: 34508259 Free PMC article.
LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions.
Serra SA, Stojakovic P, Amat R, Rubio-Moscardo F, Latorre P, Seisenbacher G, Canadell D, Böttcher R, Aregger M, Moffat J, de Nadal E, Valverde MA, Posas F. Serra SA, et al. Among authors: aregger m. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2025013118. doi: 10.1073/pnas.2025013118. Proc Natl Acad Sci U S A. 2021. PMID: 34083438 Free PMC article.
26 results