Chappell GA - Search Results

1

Enabling novel paradigms: a biological questions-based approach to human chemical hazard and drug safety assessment.

Berridge BR, Bucher JR, Sistare F, Stevens JL, Chappell GA, Clemons M, Snow S, Wignall J, Shipkowski KA. Berridge BR, et al. Among authors: chappell ga. Toxicol Sci. 2024 Feb 28;198(1):4-13. doi: 10.1093/toxsci/kfad124. Toxicol Sci. 2024. PMID: 38134427 Free PMC article.

2

Assessment of the mode of action underlying development of forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans.

Thompson CM, Suh M, Proctor DM, Chappell G, Borghoff S, Ellis-Hutchings R, Wiench K, Finch L. Thompson CM, et al. Regul Toxicol Pharmacol. 2018 Jul;96:178-189. doi: 10.1016/j.yrtph.2018.05.006. Epub 2018 May 5. Regul Toxicol Pharmacol. 2018. PMID: 29738809 Free article. Review.

3

Evaluation of Transcriptomic Responses in Livers of Mice Exposed to the Short-Chain PFAS Compound HFPO-DA.

Heintz MM, Chappell GA, Thompson CM, Haws LC. Heintz MM, et al. Among authors: chappell ga. Front Toxicol. 2022 Jun 27;4:937168. doi: 10.3389/ftox.2022.937168. eCollection 2022. Front Toxicol. 2022. PMID: 35832492 Free PMC article.

4

Review of transcriptomic responses to hexavalent chromium exposure in lung cells supports a role of epigenetic mediators in carcinogenesis.

Rager JE, Suh M, Chappell GA, Thompson CM, Proctor DM. Rager JE, et al. Among authors: chappell ga. Toxicol Lett. 2019 May 1;305:40-50. doi: 10.1016/j.toxlet.2019.01.011. Epub 2019 Jan 25. Toxicol Lett. 2019. PMID: 30690063 Review.

5

Lack of potential carcinogenicity for acesulfame potassium - Systematic evaluation and integration of mechanistic data into the totality of the evidence.

Chappell GA, Wikoff DS, Doepker CL, Borghoff SJ. Chappell GA, et al. Food Chem Toxicol. 2020 Jul;141:111375. doi: 10.1016/j.fct.2020.111375. Epub 2020 Apr 28. Food Chem Toxicol. 2020. PMID: 32360221 Free article.

6

An Adverse Outcome Pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events.

Proctor DM, Suh M, Chappell G, Borghoff SJ, Thompson CM, Wiench K, Finch L, Ellis-Hutchings R. Proctor DM, et al. Regul Toxicol Pharmacol. 2018 Jul;96:30-40. doi: 10.1016/j.yrtph.2018.04.016. Epub 2018 Apr 21. Regul Toxicol Pharmacol. 2018. PMID: 29684431 Free article. Review.

7

Lack of potential carcinogenicity for sucralose - Systematic evaluation and integration of mechanistic data into the totality of the evidence.

Chappell GA, Borghoff SJ, Pham LL, Doepker CL, Wikoff DS. Chappell GA, et al. Food Chem Toxicol. 2020 Jan;135:110898. doi: 10.1016/j.fct.2019.110898. Epub 2019 Oct 22. Food Chem Toxicol. 2020. PMID: 31654706 Free article.

8

Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1,3-butadiene in male C57BL/6J mice.

Chappell G, Kobets T, O'Brien B, Tretyakova N, Sangaraju D, Kosyk O, Sexton KG, Bodnar W, Pogribny IP, Rusyn I. Chappell G, et al. Toxicol Sci. 2014 Dec;142(2):375-84. doi: 10.1093/toxsci/kfu191. Epub 2014 Sep 18. Toxicol Sci. 2014. PMID: 25237060 Free PMC article.

9

A Framework for Systematic Evaluation and Quantitative Integration of Mechanistic Data in Assessments of Potential Human Carcinogens.

Wikoff DS, Rager JE, Chappell GA, Fitch S, Haws L, Borghoff SJ. Wikoff DS, et al. Among authors: chappell ga. Toxicol Sci. 2019 Feb 1;167(2):322-335. doi: 10.1093/toxsci/kfy279. Toxicol Sci. 2019. PMID: 30423162

10

Assessment of Mechanistic Data for Hexavalent Chromium-Induced Rodent Intestinal Cancer Using the Key Characteristics of Carcinogens.

Chappell GA, Wikoff DS, Thompson CM. Chappell GA, et al. Toxicol Sci. 2021 Feb 26;180(1):38-50. doi: 10.1093/toxsci/kfaa187. Toxicol Sci. 2021. PMID: 33404626 Free PMC article.

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