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868 results

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Chromosome 8p engineering reveals increased metastatic potential targetable by patient-specific synthetic lethality in liver cancer.
Huth T, Dreher EC, Lemke S, Fritzsche S, Sugiyanto RN, Castven D, Ibberson D, Sticht C, Eiteneuer E, Jauch A, Pusch S, Albrecht T, Goeppert B, Candia J, Wang XW, Ji J, Marquardt JU, Nahnsen S, Schirmacher P, Roessler S. Huth T, et al. Among authors: schirmacher p. Sci Adv. 2023 Dec 22;9(51):eadh1442. doi: 10.1126/sciadv.adh1442. Epub 2023 Dec 22. Sci Adv. 2023. PMID: 38134284 Free PMC article.
Deep Learning-Enabled Diagnosis of Liver Adenocarcinoma.
Albrecht T, Rossberg A, Albrecht JD, Nicolay JP, Straub BK, Gerber TS, Albrecht M, Brinkmann F, Charbel A, Schwab C, Schreck J, Brobeil A, Flechtenmacher C, von Winterfeld M, Köhler BC, Springfeld C, Mehrabi A, Singer S, Vogel MN, Neumann O, Stenzinger A, Schirmacher P, Weis CA, Roessler S, Kather JN, Goeppert B. Albrecht T, et al. Among authors: schirmacher p. Gastroenterology. 2023 Nov;165(5):1262-1275. doi: 10.1053/j.gastro.2023.07.026. Epub 2023 Aug 9. Gastroenterology. 2023. PMID: 37562657 Free article.
Etiology-independent activation of the LTβ-LTβR-RELB axis drives aggressiveness and predicts poor prognosis in HCC.
Scherr AL, Nader L, Xu K, Elssner C, Ridder DA, Nichetti F, Mastel M, Fritzsche S, Kelmendi E, Schmitt N, Hoffmeister-Wittmann P, Weiler SME, Korell F, Albrecht T, Schwab M, Isele H, Kessler A, Hüllein J, Seretny A, Ye L, Urbanik T, Welte S, Leblond AL, Heilig CE, Rahbari M, Ali A, Gallage S, Lenoir B, Wilhelm N, Gärtner U, Ogrodnik SJ, Springfeld C, Tschaharganeh D, Fröhling S, Longerich T, Schulze-Bergkamen H, Jäger D, Brandl L, Schirmacher P, Straub BK, Weber A, De Toni EN, Goeppert B, Heikenwalder M, Jackstadt R, Roessler S, Breuhahn K, Köhler BC. Scherr AL, et al. Among authors: schirmacher p. Hepatology. 2024 Aug 1;80(2):278-294. doi: 10.1097/HEP.0000000000000657. Epub 2023 Nov 2. Hepatology. 2024. PMID: 37916976
Combined analysis of albumin in situ hybridisation and C reactive protein immunohistochemistry for the diagnosis of intrahepatic cholangiocarcinoma: towards a molecular classification paradigm.
Albrecht T, Rossberg A, Rose F, Breuhahn K, Baumann EM, Tóth M, Brinkmann F, Charbel A, Vogel MN, Köhler B, Mehrabi A, Büchler MW, Singer S, Solass W, Straub B, Schirmacher P, Roessler S, Goeppert B. Albrecht T, et al. Among authors: schirmacher p. J Clin Pathol. 2024 May 15:jcp-2024-209429. doi: 10.1136/jcp-2024-209429. Online ahead of print. J Clin Pathol. 2024. PMID: 38749660 Free article.
Whole-exome sequencing reveals novel cancer genes and actionable targets in biliary tract cancers in primary sclerosing cholangitis.
Grimsrud MM, Forster M, Goeppert B, Hemmrich-Stanisak G, Sax I, Grzyb K, Braadland PR, Charbel A, Metzger C, Albrecht T, Steiert TA, Schlesner M, Manns MP, Vogel A, Yaqub S, Karlsen TH, Schirmacher P, Boberg KM, Franke A, Roessler S, Folseraas T. Grimsrud MM, et al. Among authors: schirmacher p. Hepatol Commun. 2024 Jul 5;8(7):e0461. doi: 10.1097/HC9.0000000000000461. eCollection 2024 Jul 1. Hepatol Commun. 2024. PMID: 38967597 Free PMC article.
RAGE is a key regulator of ductular reaction-mediated fibrosis during cholestasis.
Lam WM, Gabernet G, Poth T, Sator-Schmitt M, Oquendo MB, Kast B, Lohr S, de Ponti A, Weiß L, Schneider M, Helm D, Müller-Decker K, Schirmacher P, Heikenwälder M, Klingmüller U, Schneller D, Geisler F, Nahnsen S, Angel P. Lam WM, et al. Among authors: schirmacher p. EMBO Rep. 2025 Jan 2. doi: 10.1038/s44319-024-00356-7. Online ahead of print. EMBO Rep. 2025. PMID: 39747668 Free article.
An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets.
Griger J, Widholz SA, Jesinghaus M, de Andrade Krätzig N, Lange S, Engleitner T, Montero JJ, Zhigalova E, Öllinger R, Suresh V, Winkler W, Lier S, Baranov O, Trozzo R, Ben Khaled N, Chakraborty S, Yu J, Konukiewitz B, Steiger K, Pfarr N, Rajput A, Sailer D, Keller G, Schirmacher P, Röcken C, Fagerstedt KW, Mayerle J, Schmidt-Supprian M, Schneider G, Weichert W, Calado DP, Sommermann T, Klöppel G, Rajewsky K, Saur D, Rad R. Griger J, et al. Among authors: schirmacher p. Cancer Cell. 2023 Jul 10;41(7):1327-1344.e10. doi: 10.1016/j.ccell.2023.06.001. Epub 2023 Jun 22. Cancer Cell. 2023. PMID: 37352862 Free article.
Leveraging Off-Target Reads in Panel Sequencing for Homologous Recombination Repair Deficiency Screening in Tumor.
Ball M, Ourailidis I, Kluck K, Menzel M, Kirchner M, Allgäuer M, Tay TKY, Schnecko F, Volckmar AL, Goldschmid H, Neuman O, Fröhling S, Schirmacher P, Budczies J, Stenzinger A, Kazdal D. Ball M, et al. Among authors: schirmacher p. J Mol Diagn. 2024 Jun;26(6):479-486. doi: 10.1016/j.jmoldx.2024.02.008. Epub 2024 Mar 22. J Mol Diagn. 2024. PMID: 38522840 Free article.
DNA-Methylome-Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy.
Tawk B, Rein K, Schwager C, Knoll M, Wirkner U, Hörner-Rieber J, Liermann J, Kurth I, Balermpas P, Rödel C, Linge A, Löck S, Lohaus F, Tinhofer I, Krause M, Stuschke M, Grosu AL, Zips D, Combs SE, Belka C, Stenzinger A, Herold-Mende C, Baumann M, Schirmacher P, Debus J, Abdollahi A. Tawk B, et al. Among authors: schirmacher p. Clin Cancer Res. 2023 Aug 15;29(16):3051-3064. doi: 10.1158/1078-0432.CCR-22-3790. Clin Cancer Res. 2023. PMID: 37058257 Free PMC article.
868 results