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Genome-wide CRISPR-Cas 9 screens identify BCL family members as modulators of response to regorafenib in experimental glioma.
Haeusser LA, Becker H, Kuhlburger L, Zago M, Walter B, Tsiami F, Erdmann S, Trampert J, Surender S, Stahl A, Templin M, Wegner E, Schmidt T, Schmees C, Casadei N, Sevenich L, Claassen M, Nahnsen S, Beck S, Merk DJ, Tabatabai G. Haeusser LA, et al. Among authors: nahnsen s. Neuro Oncol. 2025 Jan 4:noae278. doi: 10.1093/neuonc/noae278. Online ahead of print. Neuro Oncol. 2025. PMID: 39756423
RAGE is a key regulator of ductular reaction-mediated fibrosis during cholestasis.
Lam WM, Gabernet G, Poth T, Sator-Schmitt M, Oquendo MB, Kast B, Lohr S, de Ponti A, Weiß L, Schneider M, Helm D, Müller-Decker K, Schirmacher P, Heikenwälder M, Klingmüller U, Schneller D, Geisler F, Nahnsen S, Angel P. Lam WM, et al. Among authors: nahnsen s. EMBO Rep. 2025 Jan 2. doi: 10.1038/s44319-024-00356-7. Online ahead of print. EMBO Rep. 2025. PMID: 39747668 Free article.
Building pangenome graphs.
Garrison E, Guarracino A, Heumos S, Villani F, Bao Z, Tattini L, Hagmann J, Vorbrugg S, Marco-Sola S, Kubica C, Ashbrook DG, Thorell K, Rusholme-Pilcher RL, Liti G, Rudbeck E, Golicz AA, Nahnsen S, Yang Z, Mwaniki MN, Nobrega FL, Wu Y, Chen H, de Ligt J, Sudmant PH, Huang S, Weigel D, Soranzo N, Colonna V, Williams RW, Prins P. Garrison E, et al. Among authors: nahnsen s. Nat Methods. 2024 Nov;21(11):2008-2012. doi: 10.1038/s41592-024-02430-3. Epub 2024 Oct 21. Nat Methods. 2024. PMID: 39433878
Cluster-efficient pangenome graph construction with nf-core/pangenome.
Heumos S, Heuer ML, Hanssen F, Heumos L, Guarracino A, Heringer P, Ehmele P, Prins P, Garrison E, Nahnsen S. Heumos S, et al. Among authors: nahnsen s. Bioinformatics. 2024 Nov 1;40(11):btae609. doi: 10.1093/bioinformatics/btae609. Bioinformatics. 2024. PMID: 39400346 Free PMC article.
nf-core/airrflow: An adaptive immune receptor repertoire analysis workflow employing the Immcantation framework.
Gabernet G, Marquez S, Bjornson R, Peltzer A, Meng H, Aron E, Lee NY, Jensen CG, Ladd D, Polster M, Hanssen F, Heumos S; nf-core community; Yaari G, Kowarik MC, Nahnsen S, Kleinstein SH. Gabernet G, et al. Among authors: nahnsen s. PLoS Comput Biol. 2024 Jul 26;20(7):e1012265. doi: 10.1371/journal.pcbi.1012265. eCollection 2024 Jul. PLoS Comput Biol. 2024. PMID: 39058741 Free PMC article.
Pangenome graph layout by Path-Guided Stochastic Gradient Descent.
Heumos S, Guarracino A, Schmelzle JM, Li J, Zhang Z, Hagmann J, Nahnsen S, Prins P, Garrison E. Heumos S, et al. Among authors: nahnsen s. Bioinformatics. 2024 Jul 1;40(7):btae363. doi: 10.1093/bioinformatics/btae363. Bioinformatics. 2024. PMID: 38960860 Free PMC article.
Functionally-instructed modifiers of response to ATR inhibition in experimental glioma.
Walter B, Hirsch S, Kuhlburger L, Stahl A, Schnabel L, Wisser S, Haeusser LA, Tsiami F, Plöger S, Aghaallaei N, Dick AM, Skokowa J, Schmees C, Templin M, Schenke-Layland K, Tatagiba M, Nahnsen S, Merk DJ, Tabatabai G. Walter B, et al. Among authors: nahnsen s. J Exp Clin Cancer Res. 2024 Mar 12;43(1):77. doi: 10.1186/s13046-024-02995-z. J Exp Clin Cancer Res. 2024. PMID: 38475864 Free PMC article.
66 results