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66 results

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Page 1
MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686.
Heinrich T, Schwarz D, Petersson C, Gunera J, Garg S, Schneider R, Keil M, Grimmeisen L, Unzue Lopez A, Albers L, Schlesiger S, Gambardella A, Bomke J, Carswell E, Schilke H, Diehl P, Doerfel B, Musil D, Trivier E, Broome R, Marshall S, Balsiger A, Friedrich E, Lemos AR, Santos SP, Sousa PMF, Freire F, Bandeiras TM, Bortoluzzi A, Wienke D. Heinrich T, et al. Among authors: broome r. J Med Chem. 2024 Dec 20. doi: 10.1021/acs.jmedchem.4c01949. Online ahead of print. J Med Chem. 2024. PMID: 39704449
Discovery of reversible and covalent TEAD 1 selective inhibitors MSC-1254 and MSC-5046 based on one scaffold.
Carswell E, Heinrich T, Petersson C, Gunera J, Garg S, Schwarz D, Schlesiger S, Fischer F, Eichhorn T, Calder M, Smith G, MacDonald E, Wilson H, Hazel K, Trivier E, Broome R, Balsiger A, Sirohi S, Musil D, Freire F, Schilke H, Dillon C, Wienke D. Carswell E, et al. Among authors: broome r. Bioorg Med Chem Lett. 2024 Dec 1;114:129981. doi: 10.1016/j.bmcl.2024.129981. Epub 2024 Oct 5. Bioorg Med Chem Lett. 2024. PMID: 39369801
Clinical Outcomes and Healthcare Resource Utilization for Patients With Lower-Risk Myelodysplastic Syndromes Treated With Erythropoiesis-Stimulating Agents.
Garcia-Manero G, Matsuno RK, McBride A, Mohammed H, Idryo D, Broome R, Herriman A, Johnson T, Wilkinson K, Schrag A, Johanson C, Izano M, Makinde A, Mukherjee S. Garcia-Manero G, et al. Among authors: broome r. Clin Lymphoma Myeloma Leuk. 2024 Sep;24(9):e283-e292. doi: 10.1016/j.clml.2024.05.007. Epub 2024 May 7. Clin Lymphoma Myeloma Leuk. 2024. PMID: 38871557 Free article.
Neurological outcome following out of hospital cardiac arrest: Evaluation of performance of existing risk prediction models in a UK cohort.
Livesey JA, Lone N, Black E, Broome R, Syme A, Keating S, Elliott L, McCahill C, Simpson G, Grant H, Auld F, Garrioch S, Hay A, Craven TH. Livesey JA, et al. Among authors: broome r. J Intensive Care Soc. 2023 Dec 21;25(2):131-139. doi: 10.1177/17511437231214146. eCollection 2024 May. J Intensive Care Soc. 2023. PMID: 38737314 Free PMC article.
Climate change, environmental extremes, and human health in Australia: challenges, adaptation strategies, and policy gaps.
Xu R, Yu P, Liu Y, Chen G, Yang Z, Zhang Y, Wu Y, Beggs PJ, Zhang Y, Boocock J, Ji F, Hanigan I, Jay O, Bi P, Vargas N, Leder K, Green D, Quail K, Huxley R, Jalaludin B, Hu W, Dennekamp M, Vardoulakis S, Bone A, Abrahams J, Johnston FH, Broome R, Capon T, Li S, Guo Y. Xu R, et al. Among authors: broome r. Lancet Reg Health West Pac. 2023 Nov 15;40:100936. doi: 10.1016/j.lanwpc.2023.100936. eCollection 2023 Nov. Lancet Reg Health West Pac. 2023. PMID: 38116505 Free PMC article. Review.
Acute health effects of bushfire smoke on mortality in Sydney, Australia.
Jegasothy E, Hanigan IC, Van Buskirk J, Morgan GG, Jalaludin B, Johnston FH, Guo Y, Broome RA. Jegasothy E, et al. Among authors: broome ra. Environ Int. 2023 Jan;171:107684. doi: 10.1016/j.envint.2022.107684. Epub 2022 Dec 10. Environ Int. 2023. PMID: 36577296 Free article.
Epidemiology of interstitial lung disease in patients with metastatic breast cancer at baseline and after treatment with HER2-directed therapy: a real-world data analysis.
Law JW, Campbell A, Weller C, Johanson C, Broome R, Piault E, Izano M, Schrag A, Tran M, Brown TD, Kaplan HG. Law JW, et al. Among authors: broome r. Breast Cancer Res Treat. 2022 Dec;196(3):603-611. doi: 10.1007/s10549-022-06738-6. Epub 2022 Oct 6. Breast Cancer Res Treat. 2022. PMID: 36201127 Free PMC article.
Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106.
Heinrich T, Peterson C, Schneider R, Garg S, Schwarz D, Gunera J, Seshire A, Kötzner L, Schlesiger S, Musil D, Schilke H, Doerfel B, Diehl P, Böpple P, Lemos AR, Sousa PMF, Freire F, Bandeiras TM, Carswell E, Pearson N, Sirohi S, Hooker M, Trivier E, Broome R, Balsiger A, Crowden A, Dillon C, Wienke D. Heinrich T, et al. Among authors: broome r. J Med Chem. 2022 Jul 14;65(13):9206-9229. doi: 10.1021/acs.jmedchem.2c00403. Epub 2022 Jun 28. J Med Chem. 2022. PMID: 35763499
Real-World Treatment Patterns and Clinical Effectiveness of Palbociclib Plus an Aromatase Inhibitor as First-Line Therapy in Advanced/Metastatic Breast Cancer: Analysis from the US Syapse Learning Health Network.
Law JW, Mitra D, Kaplan HG, Alfred T, Brufsky AM, Emir B, McCracken H, Liu X, Broome RG, Zhang C, DiCristo C, Chen C. Law JW, et al. Among authors: broome rg. Curr Oncol. 2022 Feb 12;29(2):1047-1061. doi: 10.3390/curroncol29020089. Curr Oncol. 2022. PMID: 35200588 Free PMC article.
66 results