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Page 1
IL-33 is associated with alveolar dysfunction in patients with viral lower respiratory tract disease.
Scott IC, Zuydam NV, Cann JA, Negri VA, Tsafou K, Killick H, Liu Z, McCrae C, Rees DG, England E, Guscott MA, Houslay K, McCormick D, Freeman A, Schofield D, Freeman A, Cohen ES, Thwaites R, Brohawn Z, Platt A, Openshaw PJM, Semple MG, Baillie JK, Wilkinson T; ISARIC4C Investigators. Scott IC, et al. Among authors: killick h. Mucosal Immunol. 2024 Dec 9:S1933-0219(24)00124-7. doi: 10.1016/j.mucimm.2024.12.001. Online ahead of print. Mucosal Immunol. 2024. PMID: 39662674 Free article.
Population pharmacokinetic/target engagement modelling of tozorakimab in healthy volunteers and patients with chronic obstructive pulmonary disease.
Sadiq MW, Yu H, Åstrand M, Scott IC, Williams A, Hewitt L, White N, Killick H, Gavala M, Cohen ES, Reid F, Kell C, Pandya H, Jimenez E. Sadiq MW, et al. Among authors: killick h. Br J Clin Pharmacol. 2024 Dec;90(12):3286-3295. doi: 10.1111/bcp.16195. Epub 2024 Aug 25. Br J Clin Pharmacol. 2024. PMID: 39183511 Free PMC article. Clinical Trial.
A Randomized Phase I Study of the Anti-Interleukin-33 Antibody Tozorakimab in Healthy Adults and Patients With Chronic Obstructive Pulmonary Disease.
Reid F, Singh D, Albayaty M, Moate R, Jimenez E, Sadiq MW, Howe D, Gavala M, Killick H, Williams A, Krishnan S, Godwood A, Shukla A, Hewitt L, Lei A, Kell C, Pandya H, Newcombe P, White N, Scott IC, Cohen ES. Reid F, et al. Among authors: killick h. Clin Pharmacol Ther. 2024 Mar;115(3):565-575. doi: 10.1002/cpt.3147. Epub 2024 Jan 24. Clin Pharmacol Ther. 2024. PMID: 38115209 Clinical Trial.
Nasal IL-13 production identifies patients with late-phase allergic responses.
Campion NJ, Villazala-Merino S, Thwaites RS, Stanek V, Killick H, Pertsinidou E, Zghaebi M, Toth J, Fröschl R, Perkmann T, Gangl K, Schneider S, Ristl R, Scott IC, Cohen ES, Molin M, Focke-Tejkl M, Regelsberger G, Hansel TT, Valenta R, Niederberger-Leppin V, Eckl-Dorna J. Campion NJ, et al. Among authors: killick h. J Allergy Clin Immunol. 2023 Nov;152(5):1167-1178.e12. doi: 10.1016/j.jaci.2023.06.026. Epub 2023 Aug 1. J Allergy Clin Immunol. 2023. PMID: 37536510 Free article. Clinical Trial.
Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex.
Strickson S, Houslay KF, Negri VA, Ohne Y, Ottosson T, Dodd RB, Huntington CC, Baker T, Li J, Stephenson KE, O'Connor AJ, Sagawe JS, Killick H, Moore T, Rees DG, Koch S, Sanden C, Wang Y, Gubbins E, Ghaedi M, Kolbeck R, Saumyaa S, Erjefält JS, Sims GP, Humbles AA, Scott IC, Romero Ros X, Cohen ES. Strickson S, et al. Among authors: killick h. Eur Respir J. 2023 Sep 28;62(3):2202210. doi: 10.1183/13993003.02210-2022. Print 2023 Sep. Eur Respir J. 2023. PMID: 37442582 Free PMC article.
Neutrophil GM-CSF receptor dynamics in acute lung injury.
De Alessandris S, Ferguson GJ, Dodd AJ, Juss JK, Devaprasad A, Piper S, Wyatt O, Killick H, Corkill DJ, Cohen ES, Pandit A, Radstake TRDJ, Simmonds R, Condliffe AM, Sleeman MA, Cowburn AS, Finch DK, Chilvers ER. De Alessandris S, et al. Among authors: killick h. J Leukoc Biol. 2019 Jun;105(6):1183-1194. doi: 10.1002/JLB.3MA0918-347R. Epub 2019 Apr 3. J Leukoc Biol. 2019. PMID: 30942918 Free PMC article.