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Page 1
Mitochondrial DNA Copy Number Variation in Asthma Risk, Severity, and Exacerbations.
Xu W, Hong YS, Hu B, Comhair SAA, Janocha AJ, Zein JG, Chen R, Meyers DA, Mauger DT, Ortega VE, Bleecker ER, Castro M, Denlinger LC, Fahy JV, Israel E, Levy BD, Jarjour NN, Moore WC, Wenzel SE, Gaston B, Liu C, Arking DE, Erzurum SC; National Heart, Lung, and Blood Institute (NHLBI) Severe Asthma Research Program (SARP) and TOPMed mtDNA Working Group in NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. Xu W, et al. Among authors: fahy jv. medRxiv [Preprint]. 2023 Dec 5:2023.12.05.23299392. doi: 10.1101/2023.12.05.23299392. medRxiv. 2023. Update in: J Allergy Clin Immunol. 2024 Sep 3:S0091-6749(24)00906-0. doi: 10.1016/j.jaci.2024.08.022 PMID: 38106101 Free PMC article. Updated. Preprint.
Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level.
Lazarus SC, Krishnan JA, King TS, Lang JE, Blake KV, Covar R, Lugogo N, Wenzel S, Chinchilli VM, Mauger DT, Dyer AM, Boushey HA, Fahy JV, Woodruff PG, Bacharier LB, Cabana MD, Cardet JC, Castro M, Chmiel J, Denlinger L, DiMango E, Fitzpatrick AM, Gentile D, Hastie A, Holguin F, Israel E, Jackson D, Kraft M, LaForce C, Lemanske RF Jr, Martinez FD, Moore W, Morgan WJ, Moy JN, Myers R, Peters SP, Phipatanakul W, Pongracic JA, Que L, Ross K, Smith L, Szefler SJ, Wechsler ME, Sorkness CA; National Heart, Lung, and Blood Institute AsthmaNet. Lazarus SC, et al. Among authors: fahy jv. N Engl J Med. 2019 May 23;380(21):2009-2019. doi: 10.1056/NEJMoa1814917. Epub 2019 May 19. N Engl J Med. 2019. PMID: 31112384 Free PMC article. Clinical Trial.
Persistent mucus plugs in proximal airways are consequential for airflow limitation in asthma.
Huang BK, Elicker BM, Henry TS, Kallianos KG, Hahn LD, Tang M, Heng F, McCulloch CE, Bhakta NR, Majumdar S, Choi J, Denlinger LC, Fain SB, Hastie AT, Hoffman EA, Israel E, Jarjour NN, Levy BD, Mauger DT, Sumino K, Wenzel SE, Castro M, Woodruff PG, Fahy JV, Sarp FTNSARP. Huang BK, et al. Among authors: fahy jv. JCI Insight. 2024 Feb 8;9(3):e174124. doi: 10.1172/jci.insight.174124. JCI Insight. 2024. PMID: 38127464 Free PMC article.
Serum cAMP levels are increased in patients with asthma.
An SS, Cao G, Ahn K, Lee J, Jung DY, Denlinger L, Fahy J, Israel E, Moore W, Phillips B, Mauger D, Wenzel S, Panettieri RA Jr. An SS, et al. J Clin Invest. 2025 Jan 7:e186937. doi: 10.1172/JCI186937. Online ahead of print. J Clin Invest. 2025. PMID: 39774028 Free article. No abstract available.
In office sampling of eosinophil peroxidase to diagnose eosinophilic chronic rhinosinusitis.
Callander JK, Charbit AR, Khanna K, Fahy JV, Tang M, Liegeois M, Pletcher SD, Goldberg AN, Gurrola JG 2nd, Murr AH, Butrymowicz A, Loftus PA. Callander JK, et al. Among authors: fahy jv. Int Forum Allergy Rhinol. 2025 Jan;15(1):36-44. doi: 10.1002/alr.23448. Epub 2024 Sep 13. Int Forum Allergy Rhinol. 2025. PMID: 39269218 Free PMC article.
Multicohort Analysis of Bronchial Epithelial Cell Expression in Healthy Subjects and Patients with Asthma Reveals Four Clinically Distinct Clusters.
Lee I, Ganesan A, Kalesinskas L, Zheng H, Ahn HC, Christenson S, Erzurum SC, Zein J, Bleecker ER, Meyers DA, Castro M, Fahy JV, Israel E, Jarjour NN, Moore W, Wenzel SE, Mauger DT, Levy BD, Woodruff PG, Ortega VE, Khatri P. Lee I, et al. Among authors: fahy jv. Am J Respir Cell Mol Biol. 2024 Dec 19. doi: 10.1165/rcmb.2024-0125OC. Online ahead of print. Am J Respir Cell Mol Biol. 2024. PMID: 39700523
Type 1 Immune Responses Related to Viral Infection Influence Corticosteroid Response in Asthma.
Fahy JV, Jackson ND, Sajuthi SP, Pruesse E, Moore CM, Everman JL, Rios C, Tang M, Gauthier M, Wenzel SE, Bleecker ER, Castro M, Comhair SA, Erzurum SC, Hastie AT, Moore W, Israel E, Levy BD, Denlinger L, Jarjour NN, Johansson MW, Mauger DT, Phillips BR, Sumino K, Woodruff PG, Peters MC, Seibold MA; National Heart, Lung, and Blood Institute Severe Asthma Research Program-3. Fahy JV, et al. Am J Respir Crit Care Med. 2024 Nov 27. doi: 10.1164/rccm.202402-0403OC. Online ahead of print. Am J Respir Crit Care Med. 2024. PMID: 39601762
Development of an asthma health-care burden score as a measure of severity and predictor of remission in SARP III and U-BIOPRED: results from two major longitudinal asthma cohorts.
Zein JG, Zounemat-Kerman N, Adcock IM, Hu B, Attaway A, Castro M, Dahlén SE, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Hastie AT, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore W, Peters MC, Sumino K, Townsend E, Woodruff P, Ortega VE, Wenzel SE, Meyers DA, Chung KF, Bleecker ER; Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) Consortium and the the US National Heart, Lung, and Blood Institute Severe Asthma Research Program (SARP III). Zein JG, et al. Among authors: fahy jv. Lancet Respir Med. 2025 Jan;13(1):35-46. doi: 10.1016/S2213-2600(24)00250-9. Epub 2024 Nov 22. Lancet Respir Med. 2025. PMID: 39586307
Mitochondrial DNA copy number variation in asthma risk, severity, and exacerbations.
Xu W, Hong YS, Hu B, Comhair SAA, Janocha AJ, Zein JG, Chen R, Meyers DA, Mauger DT, Ortega VE, Bleecker ER, Castro M, Denlinger LC, Fahy JV, Israel E, Levy BD, Jarjour NN, Moore WC, Wenzel SE, Gaston B, Liu C, Arking DE, Erzurum SC; National Heart, Lung, and Blood Institute (NHLBI) Severe Asthma Research Program and TOPMed mtDNA Working Group in NHLBI Trans-omics for Precision Medicine (TOPMed) Consortium. Xu W, et al. Among authors: fahy jv. J Allergy Clin Immunol. 2024 Sep 3:S0091-6749(24)00906-0. doi: 10.1016/j.jaci.2024.08.022. Online ahead of print. J Allergy Clin Immunol. 2024. PMID: 39237012
Peroxidase-mediated mucin cross-linking drives pathologic mucus gel formation in IL-13-stimulated airway epithelial cells.
Liegeois MA, Braunreuther M, Charbit AR, Raymond WW, Tang M, Woodruff PG, Christenson SA, Castro M, Erzurum SC, Israel E, Jarjour NN, Levy BD, Moore WC, Wenzel SE, Fuller GG, Fahy JV. Liegeois MA, et al. Among authors: fahy jv. JCI Insight. 2024 Jun 18;9(15):e181024. doi: 10.1172/jci.insight.181024. JCI Insight. 2024. PMID: 38889046 Free PMC article.
233 results