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Structures, functions and adaptations of the human LINE-1 ORF2 protein.
Baldwin ET, van Eeuwen T, Hoyos D, Zalevsky A, Tchesnokov EP, Sánchez R, Miller BD, Di Stefano LH, Ruiz FX, Hancock M, Işik E, Mendez-Dorantes C, Walpole T, Nichols C, Wan P, Riento K, Halls-Kass R, Augustin M, Lammens A, Jestel A, Upla P, Xibinaku K, Congreve S, Hennink M, Rogala KB, Schneider AM, Fairman JE, Christensen SM, Desrosiers B, Bisacchi GS, Saunders OL, Hafeez N, Miao W, Kapeller R, Zaller DM, Sali A, Weichenrieder O, Burns KH, Götte M, Rout MP, Arnold E, Greenbaum BD, Romero DL, LaCava J, Taylor MS. Baldwin ET, et al. Among authors: gotte m. Nature. 2024 Feb;626(7997):194-206. doi: 10.1038/s41586-023-06947-z. Epub 2023 Dec 14. Nature. 2024. PMID: 38096902 Free PMC article.
Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms.
Ehteshami M, Beilhartz GL, Scarth BJ, Tchesnokov EP, McCormick S, Wynhoven B, Harrigan PR, Götte M. Ehteshami M, et al. Among authors: gotte m. J Biol Chem. 2008 Aug 8;283(32):22222-32. doi: 10.1074/jbc.M803521200. Epub 2008 Jun 10. J Biol Chem. 2008. PMID: 18547911 Free PMC article.
Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase.
Zahn KE, Tchesnokov EP, Götte M, Doublié S. Zahn KE, et al. Among authors: gotte m. J Biol Chem. 2011 Jul 15;286(28):25246-55. doi: 10.1074/jbc.M111.248864. Epub 2011 May 12. J Biol Chem. 2011. PMID: 21566148 Free PMC article.
However, a previously engineered chimeric DNA polymerase, constructed by mutating the homologous polymerase from bacteriophage RB69 (gp43) to express several variable elements from UL54, can bypass this obstacle because of its favorable expression and acquired sensitivity to PFA …
However, a previously engineered chimeric DNA polymerase, constructed by mutating the homologous polymerase from bacteriophage RB69 (gp43) t …
Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus.
Tchesnokov EP, Raeisimakiani P, Ngure M, Marchant D, Götte M. Tchesnokov EP, et al. Among authors: gotte m. Sci Rep. 2018 Mar 5;8(1):3970. doi: 10.1038/s41598-018-22328-3. Sci Rep. 2018. PMID: 29507309 Free PMC article.
547 results