Xiao Y - Search Results

1

Discovery of potent and selective c-Met inhibitors for MET-amplified hepatocellular carcinoma treatment.

Min W, Wang Y, Shen H, Zheng M, Tong C, Shen H, Wang D, Zhu Y, Wang X, Xiao Y, Zhang XY, Yang P. Min W, et al. Among authors: xiao y. Eur J Med Chem. 2024 Jan 15;264:116025. doi: 10.1016/j.ejmech.2023.116025. Epub 2023 Dec 5. Eur J Med Chem. 2024. PMID: 38086189

2

Design, Synthesis, and Biological Evaluation of Icaritin Derivatives as Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment.

Hou Y, Kuang W, Min W, Liu Z, Zhang F, Yuan K, Wang X, Sun C, Cheng H, Wang L, Xiao Y, Pu S, Xin GZ, Yang P. Hou Y, et al. Among authors: xiao y. J Med Chem. 2021 Oct 28;64(20):14942-14954. doi: 10.1021/acs.jmedchem.1c00087. Epub 2021 Oct 13. J Med Chem. 2021. PMID: 34644502

3

Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation.

Wang T, Cai S, Cheng Y, Zhang W, Wang M, Sun H, Guo B, Li Z, Xiao Y, Jiang S. Wang T, et al. Among authors: xiao y. J Med Chem. 2022 Mar 10;65(5):3879-3893. doi: 10.1021/acs.jmedchem.1c01682. Epub 2022 Feb 21. J Med Chem. 2022. PMID: 35188766

4

Design, Synthesis, and Evaluation of PD-1/PD-L1 Antagonists Bearing a Benzamide Scaffold.

Lu L, Qi Z, Wang T, Zhang X, Zhang K, Wang K, Cheng Y, Xiao Y, Li Z, Jiang S. Lu L, et al. Among authors: xiao y. ACS Med Chem Lett. 2022 Mar 29;13(4):586-592. doi: 10.1021/acsmedchemlett.1c00646. eCollection 2022 Apr 14. ACS Med Chem Lett. 2022. PMID: 35450381 Free PMC article.

5

Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL.

Yuan Y, Du L, Tan R, Yu Y, Jiang J, Yao A, Luo J, Tang R, Xiao Y, Sun H. Yuan Y, et al. Among authors: xiao y. J Med Chem. 2022 Jun 9;65(11):7770-7785. doi: 10.1021/acs.jmedchem.2c00083. Epub 2022 May 25. J Med Chem. 2022. PMID: 35612819

6

Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer.

Yuan K, Li Z, Kuang W, Wang X, Ji M, Chen W, Ding J, Li J, Min W, Sun C, Ye X, Lu M, Wang L, Ge H, Jiang Y, Hao H, Xiao Y, Yang P. Yuan K, et al. Among authors: xiao y. Nat Commun. 2022 May 25;13(1):2903. doi: 10.1038/s41467-022-30581-4. Nat Commun. 2022. PMID: 35614066 Free PMC article.

7

Development of Inhibitors Targeting the V-Domain Ig Suppressor of T Cell Activation Signal Pathway.

Zheng S, Zhang K, Zhang X, Xiao Y, Wang T, Jiang S. Zheng S, et al. Among authors: xiao y. J Med Chem. 2022 Sep 22;65(18):11900-11912. doi: 10.1021/acs.jmedchem.2c00803. Epub 2022 Sep 9. J Med Chem. 2022. PMID: 36083840 Review.

8

Structure-Based Design of a Dual-Targeted Covalent Inhibitor Against Papain-like and Main Proteases of SARS-CoV-2.

Yu W, Zhao Y, Ye H, Wu N, Liao Y, Chen N, Li Z, Wan N, Hao H, Yan H, Xiao Y, Lai M. Yu W, et al. Among authors: xiao y. J Med Chem. 2022 Dec 22;65(24):16252-16267. doi: 10.1021/acs.jmedchem.2c00954. Epub 2022 Dec 12. J Med Chem. 2022. PMID: 36503248

9

Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents.

Sun C, Cheng Y, Liu X, Wang G, Min W, Wang X, Yuan K, Hou Y, Li J, Zhang H, Dong H, Wang L, Lou C, Sun Y, Yu X, Deng H, Xiao Y, Yang P. Sun C, et al. Among authors: xiao y. Acta Pharm Sin B. 2022 Dec;12(12):4446-4457. doi: 10.1016/j.apsb.2022.04.007. Epub 2022 Apr 16. Acta Pharm Sin B. 2022. PMID: 36561991 Free PMC article.

10

Novel Small-Molecule PD-L1 Inhibitor Induces PD-L1 Internalization and Optimizes the Immune Microenvironment.

Sun C, Yin M, Cheng Y, Kuang Z, Liu X, Wang G, Wang X, Yuan K, Min W, Dong J, Hou Y, Hu L, Zhang G, Pei W, Wang L, Sun Y, Yu X, Xiao Y, Deng H, Yang P. Sun C, et al. Among authors: xiao y. J Med Chem. 2023 Feb 9;66(3):2064-2083. doi: 10.1021/acs.jmedchem.2c01801. Epub 2022 Dec 29. J Med Chem. 2023. PMID: 36579489

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