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Page 1
Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors.
Teuscher KB, Mills JJ, Tian J, Han C, Meyers KM, Sai J, South TM, Crow MM, Van Meveren M, Sensintaffar JL, Zhao B, Amporndanai K, Moore WJ, Stott GM, Tansey WP, Lee T, Fesik SW. Teuscher KB, et al. Among authors: south tm. J Med Chem. 2023 Dec 28;66(24):16783-16806. doi: 10.1021/acs.jmedchem.3c01529. Epub 2023 Dec 12. J Med Chem. 2023. PMID: 38085679
Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization.
Teuscher KB, Meyers KM, Wei Q, Mills JJ, Tian J, Alvarado J, Sai J, Van Meveren M, South TM, Rietz TA, Zhao B, Moore WJ, Stott GM, Tansey WP, Lee T, Fesik SW. Teuscher KB, et al. Among authors: south tm. J Med Chem. 2022 Apr 28;65(8):6287-6312. doi: 10.1021/acs.jmedchem.2c00195. Epub 2022 Apr 18. J Med Chem. 2022. PMID: 35436124 Free PMC article.
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models.
Teuscher KB, Chowdhury S, Meyers KM, Tian J, Sai J, Van Meveren M, South TM, Sensintaffar JL, Rietz TA, Goswami S, Wang J, Grieb BC, Lorey SL, Howard GC, Liu Q, Moore WJ, Stott GM, Tansey WP, Lee T, Fesik SW. Teuscher KB, et al. Among authors: south tm. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2211297120. doi: 10.1073/pnas.2211297120. Epub 2022 Dec 27. Proc Natl Acad Sci U S A. 2023. PMID: 36574664 Free PMC article.
Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PLpro).
Taylor AJ, Amporndanai K, Rietz TA, Zhao B, Thiruvaipati A, Wei Q, South TM, Crow MM, Apakama C, Sensintaffar JL, Phan J, Lee T, Fesik SW. Taylor AJ, et al. Among authors: south tm. ACS Med Chem Lett. 2024 Jul 23;15(8):1351-1357. doi: 10.1021/acsmedchemlett.4c00238. eCollection 2024 Aug 8. ACS Med Chem Lett. 2024. PMID: 39140055 Free PMC article.
Using NMR Spectroscopy To Measure Protein Binding Capacity on Gold Nanoparticles.
Perera YR, South TM, Hughes AC, Parkhurst AN, Williams OC, Davidson MB, Wilks CA, Mlsna DA, Fitzkee NC. Perera YR, et al. Among authors: south tm. J Chem Educ. 2020 Mar 10;97(3):820-824. doi: 10.1021/acs.jchemed.9b00625. Epub 2020 Jan 21. J Chem Educ. 2020. PMID: 34045774 Free PMC article.