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Applicability of free drug hypothesis to drugs with good membrane permeability that are not efflux transporter substrates: A microdialysis study in rats.
Chen C, Zhou H, Guan C, Zhang H, Li Y, Jiang X, Dong Z, Tao Y, Du J, Wang S, Zhang T, Du N, Guo J, Wu Y, Song Z, Luan H, Wang Y, Du H, Zhang S, Li C, Chang H, Wang T. Chen C, et al. Among authors: du n, du j, du h. Pharmacol Res Perspect. 2020 Apr;8(2):e00575. doi: 10.1002/prp2.575. Pharmacol Res Perspect. 2020. PMID: 32266794 Free PMC article.
Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator.
Thomson CG, Aicher TD, Cheng W, Du H, Dudgeon C, Li AH, Li B, Lightcap E, Luo D, Mulvihill M, Pan P, Rahemtulla BF, Rigby AC, Sherborne B, Sood S, Surguladze D, Talbot EPA, Tameire F, Taylor S, Wang Y, Wojnarowicz P, Xiao F, Ramurthy S. Thomson CG, et al. Among authors: du h. J Med Chem. 2024 Apr 11;67(7):5259-5271. doi: 10.1021/acs.jmedchem.3c02384. Epub 2024 Mar 26. J Med Chem. 2024. PMID: 38530741
8,050 results