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Page 1
AlphaFold2 enables accurate deorphanization of ligands to single-pass receptors.
Banhos Danneskiold-Samsøe N, Kavi D, Jude KM, Nissen SB, Wat LW, Coassolo L, Zhao M, Santana-Oikawa GA, Broido BB, Garcia KC, Svensson KJ. Banhos Danneskiold-Samsøe N, et al. Among authors: coassolo l. Cell Syst. 2024 Nov 20;15(11):1046-1060.e3. doi: 10.1016/j.cels.2024.10.004. Epub 2024 Nov 13. Cell Syst. 2024. PMID: 39541981
A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites.
Moya-Garzon MD, Wang M, Li VL, Lyu X, Wei W, Tung AS, Raun SH, Zhao M, Coassolo L, Islam H, Oliveira B, Dai Y, Spaas J, Delgado-Gonzalez A, Donoso K, Alvarez-Buylla A, Franco-Montalban F, Letian A, Ward CP, Liu L, Svensson KJ, Goldberg EL, Gardner CD, Little JP, Banik SM, Xu Y, Long JZ. Moya-Garzon MD, et al. Among authors: coassolo l. Cell. 2024 Nov 7:S0092-8674(24)01214-5. doi: 10.1016/j.cell.2024.10.032. Online ahead of print. Cell. 2024. PMID: 39536746 Free article.
A secondary β-hydroxybutyrate metabolic pathway linked to energy balance.
Moya-Garzon MD, Wang M, Li VL, Lyu X, Wei W, Tung AS, Raun SH, Zhao M, Coassolo L, Islam H, Oliveira B, Dai Y, Spaas J, Delgado-Gonzalez A, Donoso K, Alvarez-Buylla A, Franco-Montalban F, Letian A, Ward C, Liu L, Svensson KJ, Goldberg EL, Gardner CD, Little JP, Banik SM, Xu Y, Long JZ. Moya-Garzon MD, et al. Among authors: coassolo l. bioRxiv [Preprint]. 2024 Sep 9:2024.09.09.612087. doi: 10.1101/2024.09.09.612087. bioRxiv. 2024. PMID: 39314488 Free PMC article. Preprint.
PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity.
Wei W, Lyu X, Markhard AL, Fu S, Mardjuki RE, Cavanagh PE, Zeng X, Rajniak J, Lu N, Xiao S, Zhao M, Moya-Garzon MD, Truong SD, Chou JC, Wat LW, Chidambaranathan-Reghupaty S, Coassolo L, Xu D, Shen F, Huang W, Ramirez CB, Jang C, Li L, Svensson KJ, Fischbach MA, Long JZ. Wei W, et al. Among authors: coassolo l. Nature. 2024 Sep;633(8028):182-188. doi: 10.1038/s41586-024-07801-6. Epub 2024 Aug 7. Nature. 2024. PMID: 39112712 Free PMC article.
A PTER-dependent pathway of taurine metabolism linked to energy balance.
Wei W, Lyu X, Markhard AL, Fu S, Mardjuki RE, Cavanagh PE, Zeng X, Rajniak J, Lu N, Xiao S, Zhao M, Moya-Garzon MD, Truong SD, Chou JC, Wat LW, Chidambaranathan-Reghupaty S, Coassolo L, Xu D, Shen F, Huang W, Ramirez CB, Jang C, Svensson KJ, Fischbach MA, Long JZ. Wei W, et al. Among authors: coassolo l. bioRxiv [Preprint]. 2024 Mar 22:2024.03.21.586194. doi: 10.1101/2024.03.21.586194. bioRxiv. 2024. PMID: 38562797 Free PMC article. Preprint.
AlphaFold2 enables accurate deorphanization of ligands to single-pass receptors.
Danneskiold-Samsøe NB, Kavi D, Jude KM, Nissen SB, Wat LW, Coassolo L, Zhao M, Santana-Oikawa GA, Broido BB, Garcia KC, Svensson KJ. Danneskiold-Samsøe NB, et al. Among authors: coassolo l. bioRxiv [Preprint]. 2023 Dec 15:2023.03.16.531341. doi: 10.1101/2023.03.16.531341. bioRxiv. 2023. Update in: Cell Syst. 2024 Nov 20;15(11):1046-1060.e3. doi: 10.1016/j.cels.2024.10.004 PMID: 36993313 Free PMC article. Updated. Preprint.