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An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis.
Jackson JW, Frederick C Streich Jr, Pal A, Coricor G, Boston C, Brueckner CT, Canonico K, Chapron C, Cote S, Dagbay KB, Danehy FT Jr, Kavosi M, Kumar S, Lin S, Littlefield C, Looby K, Manohar R, Martin CJ, Wood M, Zawadzka A, Wawersik S, Nicholls SB, Datta A, Buckler A, Schürpf T, Carven GJ, Qatanani M, Fogel AI. Jackson JW, et al. Among authors: schurpf t. Sci Signal. 2024 Jul 9;17(844):eadn6052. doi: 10.1126/scisignal.adn6052. Epub 2024 Jul 9. Sci Signal. 2024. PMID: 38980922
Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors.
Heiser CN, Simmons AJ, Revetta F, McKinley ET, Ramirez-Solano MA, Wang J, Kaur H, Shao J, Ayers GD, Wang Y, Glass SE, Tasneem N, Chen Z, Qin Y, Kim W, Rolong A, Chen B, Vega PN, Drewes JL, Markham NO, Saleh N, Nikolos F, Vandekar S, Jones AL, Washington MK, Roland JT, Chan KS, Schürpf T, Sears CL, Liu Q, Shrubsole MJ, Coffey RJ, Lau KS. Heiser CN, et al. Among authors: schurpf t. Cell. 2023 Dec 7;186(25):5620-5637.e16. doi: 10.1016/j.cell.2023.11.006. Cell. 2023. PMID: 38065082 Free PMC article.
Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape.
Martin CJ, Datta A, Littlefield C, Kalra A, Chapron C, Wawersik S, Dagbay KB, Brueckner CT, Nikiforov A, Danehy FT Jr, Streich FC Jr, Boston C, Simpson A, Jackson JW, Lin S, Danek N, Faucette RR, Raman P, Capili AD, Buckler A, Carven GJ, Schürpf T. Martin CJ, et al. Among authors: schurpf t. Sci Transl Med. 2020 Mar 25;12(536):eaay8456. doi: 10.1126/scitranslmed.aay8456. Sci Transl Med. 2020. PMID: 32213632
How natalizumab binds and antagonizes α4 integrins.
Yu Y, Schürpf T, Springer TA. Yu Y, et al. Among authors: schurpf t. J Biol Chem. 2013 Nov 8;288(45):32314-32325. doi: 10.1074/jbc.M113.501668. Epub 2013 Sep 18. J Biol Chem. 2013. PMID: 24047894 Free PMC article.
13 results