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Pathologic vs. protective roles of hypoxia-inducible factor 1 in RPE and photoreceptors in wet vs. dry age-related macular degeneration.
Babapoor-Farrokhran S, Qin Y, Flores-Bellver M, Niu Y, Bhutto IA, Aparicio-Domingo S, Guo C, Rodrigues M, Domashevich T, Deshpande M, Megarity H, Chopde R, Eberhart CG, Canto-Soler V, Montaner S, Sodhi A. Babapoor-Farrokhran S, et al. Among authors: guo c. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2302845120. doi: 10.1073/pnas.2302845120. Epub 2023 Dec 6. Proc Natl Acad Sci U S A. 2023. PMID: 38055741 Free PMC article.
ANGPTL4 influences the therapeutic response of patients with neovascular age-related macular degeneration by promoting choroidal neovascularization.
Qin Y, Dinabandhu A, Cao X, Sanchez JC, Jee K, Rodrigues M, Guo C, Zhang J, Vancel J, Menon D, Khan NS, Ma T, Tzeng SY, Daoud Y, Green JJ, Semenza GL, Montaner S, Sodhi A. Qin Y, et al. Among authors: guo c. JCI Insight. 2022 Jul 8;7(13):e157896. doi: 10.1172/jci.insight.157896. JCI Insight. 2022. PMID: 35653189 Free PMC article.
Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice.
Zhang J, Sharma D, Dinabandhu A, Sanchez J, Applewhite B, Jee K, Deshpande M, Flores-Bellver M, Hu MW, Guo C, Salman S, Hwang Y, Anders NM, Rudek MA, Qian J, Canto-Soler MV, Semenza GL, Montaner S, Sodhi A. Zhang J, et al. Among authors: guo c. J Clin Invest. 2023 Jul 3;133(13):e163290. doi: 10.1172/JCI163290. J Clin Invest. 2023. PMID: 37227777 Free PMC article.
VEGF inhibition increases expression of HIF-regulated angiogenic genes by the RPE limiting the response of wet AMD eyes to aflibercept.
Sharma D, Lau E, Qin Y, Jee K, Rodrigues M, Guo C, Dinabandhu A, McIntyre E, Salman S, Hwang Y, Moshiri A, Semenza GL, Montaner S, Sodhi A. Sharma D, et al. Among authors: guo c. Proc Natl Acad Sci U S A. 2024 Nov 12;121(46):e2322759121. doi: 10.1073/pnas.2322759121. Epub 2024 Nov 5. Proc Natl Acad Sci U S A. 2024. PMID: 39499641 Free PMC article.
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