Kho AL - Search Results

1

Missense mutations in the central domains of cardiac myosin binding protein-C and their potential contribution to hypertrophic cardiomyopathy.

Pearce A, Ponnam S, Holt MR, Randall T, Beckingham R, Kho AL, Kampourakis T, Ehler E. Pearce A, et al. Among authors: kho al. J Biol Chem. 2024 Jan;300(1):105511. doi: 10.1016/j.jbc.2023.105511. Epub 2023 Nov 30. J Biol Chem. 2024. PMID: 38042491 Free PMC article.

2

Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance.

Iskratsch T, Lange S, Dwyer J, Kho AL, dos Remedios C, Ehler E. Iskratsch T, et al. Among authors: kho al. J Cell Biol. 2010 Dec 13;191(6):1159-72. doi: 10.1083/jcb.201005060. J Cell Biol. 2010. PMID: 21149568 Free PMC article.

3

The Cardiac Stress Response Factor Ms1 Can Bind to DNA and Has a Function in the Nucleus.

Zaleska M, Fogl C, Kho AL, Ababou A, Ehler E, Pfuhl M. Zaleska M, et al. Among authors: kho al. PLoS One. 2015 Dec 14;10(12):e0144614. doi: 10.1371/journal.pone.0144614. eCollection 2015. PLoS One. 2015. PMID: 26656831 Free PMC article.

4

Making sense of missense variants in TTN-related congenital myopathies.

Rees M, Nikoopour R, Fukuzawa A, Kho AL, Fernandez-Garcia MA, Wraige E, Bodi I, Deshpande C, Özdemir Ö, Daimagüler HS, Pfuhl M, Holt M, Brandmeier B, Grover S, Fluss J, Longman C, Farrugia ME, Matthews E, Hanna M, Muntoni F, Sarkozy A, Phadke R, Quinlivan R, Oates EC, Schröder R, Thiel C, Reimann J, Voermans N, Erasmus C, Kamsteeg EJ, Konersman C, Grosmann C, McKee S, Tirupathi S, Moore SA, Wilichowski E, Hobbiebrunken E, Dekomien G, Richard I, Van den Bergh P, Domínguez-González C, Cirak S, Ferreiro A, Jungbluth H, Gautel M. Rees M, et al. Among authors: kho al. Acta Neuropathol. 2021 Mar;141(3):431-453. doi: 10.1007/s00401-020-02257-0. Epub 2021 Jan 15. Acta Neuropathol. 2021. PMID: 33449170 Free PMC article.

5

Structure of the native myosin filament in the relaxed cardiac sarcomere.

Tamborrini D, Wang Z, Wagner T, Tacke S, Stabrin M, Grange M, Kho AL, Rees M, Bennett P, Gautel M, Raunser S. Tamborrini D, et al. Among authors: kho al. Nature. 2023 Nov;623(7988):863-871. doi: 10.1038/s41586-023-06690-5. Epub 2023 Nov 1. Nature. 2023. PMID: 37914933 Free PMC article.

6

Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin.

Wang Z, Grange M, Pospich S, Wagner T, Kho AL, Gautel M, Raunser S. Wang Z, et al. Among authors: kho al. Science. 2022 Feb 18;375(6582):eabn1934. doi: 10.1126/science.abn1934. Epub 2022 Feb 18. Science. 2022. PMID: 35175800

7

Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro.

Koch D, Kho AL, Fukuzawa A, Alexandrovich A, Vanaanen KJ, Beavil A, Pfuhl M, Rees M, Gautel M. Koch D, et al. Among authors: kho al. PLoS One. 2023 Apr 20;18(4):e0284453. doi: 10.1371/journal.pone.0284453. eCollection 2023. PLoS One. 2023. PMID: 37079638 Free PMC article.

8

The sarcomeric cytoskeleton as a target for pharmacological intervention.

Kho AL, Perera S, Alexandrovich A, Gautel M. Kho AL, et al. Curr Opin Pharmacol. 2012 Jun;12(3):347-54. doi: 10.1016/j.coph.2012.03.007. Epub 2012 Apr 4. Curr Opin Pharmacol. 2012. PMID: 22483604 Review.

9

The molecular basis for sarcomere organization in vertebrate skeletal muscle.

Wang Z, Grange M, Wagner T, Kho AL, Gautel M, Raunser S. Wang Z, et al. Among authors: kho al. Cell. 2021 Apr 15;184(8):2135-2150.e13. doi: 10.1016/j.cell.2021.02.047. Epub 2021 Mar 24. Cell. 2021. PMID: 33765442 Free PMC article.

10

Molecular noise filtering in the β-adrenergic signaling network by phospholamban pentamers.

Koch D, Alexandrovich A, Funk F, Kho AL, Schmitt JP, Gautel M. Koch D, et al. Among authors: kho al. Cell Rep. 2021 Jul 27;36(4):109448. doi: 10.1016/j.celrep.2021.109448. Cell Rep. 2021. PMID: 34320358 Free PMC article.

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