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Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion.
Sun Y, Florio TJ, Gupta S, Young MC, Marshall QF, Garfinkle SE, Papadaki GF, Truong HV, Mycek E, Li P, Farrel A, Church NL, Jabar S, Beasley MD, Kiefel BR, Yarmarkovich M, Mallik L, Maris JM, Sgourakis NG. Sun Y, et al. Sci Immunol. 2023 Dec;8(90):eadj5792. doi: 10.1126/sciimmunol.adj5792. Epub 2023 Dec 1. Sci Immunol. 2023. PMID: 38039376 Free PMC article.
Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes.
Sun Y, Young MC, Woodward CH, Danon JN, Truong H, Gupta S, Winters TJ, Burslem G, Sgourakis NG. Sun Y, et al. bioRxiv [Preprint]. 2023 Mar 18:2023.03.18.533266. doi: 10.1101/2023.03.18.533266. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2304055120. doi: 10.1073/pnas.2304055120 PMID: 36993702 Free PMC article. Updated. Preprint.
Structural principles of peptide-centric Chimeric Antigen Receptor recognition guide therapeutic expansion.
Sun Y, Florio TJ, Gupta S, Young MC, Marshall QF, Garfinkle SE, Papadaki GF, Truong HV, Mycek E, Li P, Farrel A, Church NL, Jabar S, Beasley MD, Kiefel BR, Yarmarkovich M, Mallik L, Maris JM, Sgourakis NG. Sun Y, et al. bioRxiv [Preprint]. 2023 May 24:2023.05.24.542108. doi: 10.1101/2023.05.24.542108. bioRxiv. 2023. Update in: Sci Immunol. 2023 Dec;8(90):eadj5792. doi: 10.1126/sciimmunol.adj5792 PMID: 37292750 Free PMC article. Updated. Preprint.
CryoEM structure of an MHC-I/TAPBPR peptide bound intermediate reveals the mechanism of antigen proofreading.
Sun Y, Pumroy RA, Mallik L, Chaudhuri A, Wang C, Hwang D, Danon JN, Goli KD, Moiseenkova-Bell V, Sgourakis NG. Sun Y, et al. bioRxiv [Preprint]. 2024 Aug 7:2024.08.05.606663. doi: 10.1101/2024.08.05.606663. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2025 Jan 14;122(2):e2416992122. doi: 10.1073/pnas.2416992122 PMID: 39211162 Free PMC article. Updated. Preprint.
Targeting peptide antigens using a multiallelic MHC I-binding system.
Du H, Mallik L, Hwang D, Sun Y, Kaku C, Hoces D, Sun SM, Ghinnagow R, Carro SD, Phan HAT, Gupta S, Blackson W, Lee H, Choe CA, Dersh D, Liu J, Bell B, Yang H, Papadaki GF, Young MC, Zhou E, El Nesr G, Goli KD, Eisenlohr LC, Minn AJ, Hernandez-Lopez RA, Jardine JG, Sgourakis NG, Huang PS. Du H, et al. Among authors: sun y, sun sm. Nat Biotechnol. 2024 Dec 13. doi: 10.1038/s41587-024-02505-8. Online ahead of print. Nat Biotechnol. 2024. PMID: 39672954
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