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Single-cell RNA seq-derived signatures define response patterns to atezolizumab + bevacizumab in advanced hepatocellular carcinoma.
Cappuyns S, Piqué-Gili M, Esteban-Fabró R, Philips G, Balaseviciute U, Pinyol R, Gris-Oliver A, Vandecaveye V, Abril-Fornaguera J, Montironi C, Bassaganyas L, Peix J, Zeitlhoefler M, Mesropian A, Huguet-Pradell J, Haber PK, Figueiredo I, Ioannou G, Gonzalez-Kozlova E, D'Alessio A, Mohr R, Meyer T, Lachenmayer A, Marquardt JU, Reeves HL, Edeline J, Finkelmeier F, Trojan J, Galle PR, Foerster F, Mínguez B, Montal R, Gnjatic S, Pinato DJ, Heikenwalder M, Verslype C, Van Cutsem E, Lambrechts D, Villanueva A, Dekervel J, Llovet JM. Cappuyns S, et al. J Hepatol. 2024 Dec 19:S0168-8278(24)02771-5. doi: 10.1016/j.jhep.2024.12.016. Online ahead of print. J Hepatol. 2024. PMID: 39709141 Free article.
NOTCH1 drives sexually dimorphic immune responses in hepatocellular carcinoma.
Lindblad KE, Donne R, Liebling I, Barcena-Varela M, Lozano A, Ruiz de Galarreta M, Dhainaut M, Param NJ, Giotti B, Cappuyns S, Kodama T, Wang Y, Kamphorst AO, Tsankov AM, Lujambio A. Lindblad KE, et al. Among authors: cappuyns s. Cancer Discov. 2024 Nov 19. doi: 10.1158/2159-8290.CD-24-1215. Online ahead of print. Cancer Discov. 2024. PMID: 39560425
Oncogenic role of PMEPA1 and its association with immune exhaustion and TGF-β activation in HCC.
Piqué-Gili M, Andreu-Oller C, Mesropian A, Esteban-Fabró R, Bárcena-Varela M, Ruiz de Galarreta M, Montironi C, Martinez-Quetglas I, Cappuyns S, Peix J, Keraite I, Gris-Oliver A, Fernández-Martínez E, Mauro E, Torres-Martin M, Abril-Fornaguera J, Lindblad KE, Lambrechts D, Dekervel J, Thung SN, Sia D, Lujambio A, Pinyol R, Llovet JM. Piqué-Gili M, et al. Among authors: cappuyns s. JHEP Rep. 2024 Sep 7;6(11):101212. doi: 10.1016/j.jhepr.2024.101212. eCollection 2024 Nov. JHEP Rep. 2024. PMID: 39524206 Free PMC article.
Applications of single-cell multi-omics in liver cancer.
Peeters F, Cappuyns S, Piqué-Gili M, Phillips G, Verslype C, Lambrechts D, Dekervel J. Peeters F, et al. Among authors: cappuyns s. JHEP Rep. 2024 Apr 15;6(7):101094. doi: 10.1016/j.jhepr.2024.101094. eCollection 2024 Jul. JHEP Rep. 2024. PMID: 39022385 Free PMC article. Review.
PD-1- CD45RA+ effector-memory CD8 T cells and CXCL10+ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma.
Cappuyns S, Philips G, Vandecaveye V, Boeckx B, Schepers R, Van Brussel T, Arijs I, Mechels A, Bassez A, Lodi F, Jaekers J, Topal H, Topal B, Bricard O, Qian J, Van Cutsem E, Verslype C, Lambrechts D, Dekervel J. Cappuyns S, et al. Nat Commun. 2023 Nov 29;14(1):7825. doi: 10.1038/s41467-023-43381-1. Nat Commun. 2023. PMID: 38030622 Free PMC article.
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