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Oxidation of hemoglobin in the lung parenchyma facilitates the differentiation of pneumococci into encapsulated bacteria.
Alibayov B, Scasny A, Vidal AGJ, Murin L, Wong S, Edwards KS, Eichembaun Z, Punshon T, Jackson BP, Hopp MT, McDaniel LS, Akerley BJ, Imhof D, Vidal JE. Alibayov B, et al. Among authors: scasny a. bioRxiv [Preprint]. 2023 Nov 15:2023.11.14.567109. doi: 10.1101/2023.11.14.567109. bioRxiv. 2023. PMID: 38014009 Free PMC article. Preprint.
Oxidation of hemoproteins by Streptococcus pneumoniae collapses the cell cytoskeleton and disrupts mitochondrial respiration leading to cytotoxicity of human lung cells.
Scasny A, Alibayov B, Khan F, Rao SJ, Murin L, Jop Vidal AG, Smith P, Wei L, Edwards K, Warncke K, Vidal JE. Scasny A, et al. bioRxiv [Preprint]. 2023 Jun 7:2023.06.07.544089. doi: 10.1101/2023.06.07.544089. bioRxiv. 2023. Update in: Microbiol Spectr. 2024 Jan 11;12(1):e0291223. doi: 10.1128/spectrum.02912-23 PMID: 37333138 Free PMC article. Updated. Preprint.
Oxidative Reactions Catalyzed by Hydrogen Peroxide Produced by Streptococcus pneumoniae and Other Streptococci Cause the Release and Degradation of Heme from Hemoglobin.
Alibayov B, Scasny A, Khan F, Creel A, Smith P, Vidal AGJ, Fitisemanu FM, Padilla-Benavides T, Weiser JN, Vidal JE. Alibayov B, et al. Among authors: scasny a. Infect Immun. 2022 Dec 15;90(12):e0047122. doi: 10.1128/iai.00471-22. Epub 2022 Nov 21. Infect Immun. 2022. PMID: 36409115 Free PMC article.