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1,308 results

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Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity.
Zheng Q, Tang J, Aicher A, Bou Kheir T, Sabanovic B, Ananthanarayanan P, Reina C, Chen M, Gu JM, He B, Alcala S, Behrens D, Lawlo RT, Scarpa A, Hidalgo M, Sainz B Jr, Sancho P, Heeschen C. Zheng Q, et al. Among authors: scarpa a. J Exp Clin Cancer Res. 2023 Nov 28;42(1):323. doi: 10.1186/s13046-023-02883-y. J Exp Clin Cancer Res. 2023. PMID: 38012687 Free PMC article.
Pancreatic cancer and autoimmune diseases: An association sustained by computational and epidemiological case-control approaches.
Gomez-Rubio P, Piñero J, Molina-Montes E, Gutiérrez-Sacristán A, Marquez M, Rava M, Michalski CW, Farré A, Molero X, Löhr M, Perea J, Greenhalf W, O'Rorke M, Tardón A, Gress T, Barberá VM, Crnogorac-Jurcevic T, Muñoz-Bellvís L, Domínguez-Muñoz E, Balsells J, Costello E, Yu J, Iglesias M, Ilzarbe L, Kleeff J, Kong B, Mora J, Murray L, O'Driscoll D, Poves I, Lawlor RT, Ye W, Hidalgo M, Scarpa A, Sharp L, Carrato A, Real FX, Furlong LI, Malats N; PanGenEU Study Investigators. Gomez-Rubio P, et al. Among authors: scarpa a. Int J Cancer. 2019 Apr 1;144(7):1540-1549. doi: 10.1002/ijc.31866. Epub 2018 Oct 26. Int J Cancer. 2019. PMID: 30229903
Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology.
Osuna de la Peña D, Trabulo SMD, Collin E, Liu Y, Sharma S, Tatari M, Behrens D, Erkan M, Lawlor RT, Scarpa A, Heeschen C, Mata A, Loessner D. Osuna de la Peña D, et al. Among authors: scarpa a. Nat Commun. 2021 Sep 24;12(1):5623. doi: 10.1038/s41467-021-25921-9. Nat Commun. 2021. PMID: 34561461 Free PMC article.
Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug.
Alors-Perez E, Blázquez-Encinas R, Alcalá S, Viyuela-García C, Pedraza-Arevalo S, Herrero-Aguayo V, Jiménez-Vacas JM, Mafficini A, Sánchez-Frías ME, Cano MT, Abollo-Jiménez F, Marín-Sanz JA, Cabezas-Sainz P, Lawlor RT, Luchini C, Sánchez L, Sánchez-Hidalgo JM, Ventura S, Martin-Hijano L, Gahete MD, Scarpa A, Arjona-Sánchez Á, Ibáñez-Costa A, Sainz B Jr, Luque RM, Castaño JP. Alors-Perez E, et al. Among authors: scarpa a. J Exp Clin Cancer Res. 2021 Dec 2;40(1):382. doi: 10.1186/s13046-021-02153-9. J Exp Clin Cancer Res. 2021. PMID: 34857016 Free PMC article.
Differential activity of MAPK signalling defines fibroblast subtypes in pancreatic cancer.
Veghini L, Pasini D, Fang R, Delfino P, Filippini D, Neander C, Vicentini C, Fiorini E, Lupo F, D'Agosto SL, Carbone C, Agostini A, Piro G, Rosa D, Bevere M, Markus P, Behrens D, Luchini C, Lawlor RT, Scarpa A, Biffi G, Cheung PF, Siveke JT, Corbo V. Veghini L, et al. Among authors: scarpa a. Nat Commun. 2024 Dec 3;15(1):10534. doi: 10.1038/s41467-024-54975-8. Nat Commun. 2024. PMID: 39627211 Free PMC article.
Reduced risk of pancreatic cancer associated with asthma and nasal allergies.
Gomez-Rubio P, Zock JP, Rava M, Marquez M, Sharp L, Hidalgo M, Carrato A, Ilzarbe L, Michalski C, Molero X, Farré A, Perea J, Greenhalf W, O'Rorke M, Tardón A, Gress T, Barberà V, Crnogorac-Jurcevic T, Domínguez-Muñoz E, Muñoz-Bellvís L, Alvarez-Urturi C, Balcells J, Barneo L, Costello E, Guillén-Ponce C, Kleeff J, Kong B, Lawlor R, Löhr M, Mora J, Murray L, O'Driscoll D, Peláez P, Poves I, Scarpa A, Real FX, Malats N; PanGenEU Study Investigators. Gomez-Rubio P, et al. Among authors: scarpa a. Gut. 2017 Feb;66(2):314-322. doi: 10.1136/gutjnl-2015-310442. Epub 2015 Dec 1. Gut. 2017. PMID: 26628509 Review.
Early Epigenetic Downregulation of microRNA-192 Expression Promotes Pancreatic Cancer Progression.
Botla SK, Savant S, Jandaghi P, Bauer AS, Mücke O, Moskalev EA, Neoptolemos JP, Costello E, Greenhalf W, Scarpa A, Gaida MM, Büchler MW, Strobel O, Hackert T, Giese NA, Augustin HG, Hoheisel JD. Botla SK, et al. Among authors: scarpa a. Cancer Res. 2016 Jul 15;76(14):4149-59. doi: 10.1158/0008-5472.CAN-15-0390. Epub 2016 May 23. Cancer Res. 2016. PMID: 27216198
An FGFR3 Autocrine Loop Sustains Acquired Resistance to Trastuzumab in Gastric Cancer Patients.
Piro G, Carbone C, Cataldo I, Di Nicolantonio F, Giacopuzzi S, Aprile G, Simionato F, Boschi F, Zanotto M, Mina MM, Santoro R, Merz V, Sbarbati A, de Manzoni G, Scarpa A, Tortora G, Melisi D. Piro G, et al. Among authors: scarpa a. Clin Cancer Res. 2016 Dec 15;22(24):6164-6175. doi: 10.1158/1078-0432.CCR-16-0178. Epub 2016 Jun 7. Clin Cancer Res. 2016. PMID: 27267856
Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models.
Del Curatolo A, Conciatori F, Cesta Incani U, Bazzichetto C, Falcone I, Corbo V, D'Agosto S, Eramo A, Sette G, Sperduti I, De Luca T, Marabese M, Shirasawa S, De Maria R, Scarpa A, Broggini M, Del Bufalo D, Cognetti F, Milella M, Ciuffreda L. Del Curatolo A, et al. Among authors: scarpa a. J Exp Clin Cancer Res. 2018 Jul 9;37(1):140. doi: 10.1186/s13046-018-0820-5. J Exp Clin Cancer Res. 2018. PMID: 29986755 Free PMC article.
1,308 results