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The anticoagulant effects of milvexian, a novel small molecule factor XIa inhibitor, are neutralized by activated prothrombin complex concentrates and recombinant factor VIIa in human plasma and whole blood in vitro.
Bunce M, Huang Devine Z, Chintala M. Bunce M, et al. Among authors: chintala m. Res Pract Thromb Haemost. 2024 Oct 23;8(8):102600. doi: 10.1016/j.rpth.2024.102600. eCollection 2024 Nov. Res Pract Thromb Haemost. 2024. PMID: 39687926 Free PMC article.
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
Xu G, Liu Z, Wang X, Lu T, DesJarlais RL, Thieu T, Zhang J, Devine ZH, Du F, Li Q, Milligan CM, Shaffer P, Cedervall PE, Spurlino JC, Stratton CF, Pietrak B, Szewczuk LM, Wong V, Steele RA, Bruinzeel W, Chintala M, Silva J, Gaul MD, Macielag MJ, Nargund R. Xu G, et al. Among authors: chintala m. J Med Chem. 2022 Aug 11;65(15):10419-10440. doi: 10.1021/acs.jmedchem.2c00442. Epub 2022 Jul 21. J Med Chem. 2022. PMID: 35862732
Lead Optimization to Advance Protease-Activated Receptor-1 Antagonists in Early Discovery.
Mandal M, Madeira M, Amin RP, Buevich AV, Cheng A, Labroli M, Liu X, Acton J, Pio B, Basso A, Chobanian H, Dong G, Dropinski J, Guo Y, Guo Z, Kurowski S, Korfmacher W, Lee S, Meng D, Ondeyka D, Yang Z, Zhang R, Wei H, Wu Z, Zhang F, Wollenberg G, Biftu T, Greenlee WJ, Chintala M, Maletic M, Zhu Z. Mandal M, et al. Among authors: chintala m. J Med Chem. 2022 Apr 14;65(7):5575-5592. doi: 10.1021/acs.jmedchem.1c02048. Epub 2022 Mar 29. J Med Chem. 2022. PMID: 35349275
Resilience of aquatic systems: Review and management implications.
Pelletier MC, Ebersole J, Mulvaney K, Rashleigh B, Gutierrez MN, Chintala M, Kuhn A, Molina M, Bagley M, Lane C. Pelletier MC, et al. Among authors: chintala m. Aquat Sci. 2020 Mar 28;82(2):1-44. doi: 10.1007/s00027-020-00717-z. Aquat Sci. 2020. PMID: 32489242 Free PMC article.
Bioextractive Removal of Nitrogen by Oysters in Great Bay Piscataqua River Estuary, New Hampshire, USA.
Bricker SB, Grizzle RE, Trowbridge P, Rose JM, Ferreira JG, Wellman K, Zhu C, Galimany E, Wikfors GH, Saurel C, Miller RL, Wands J, Rheault R, Steinberg J, Jacob AP, Davenport ED, Ayvazian S, Chintala M, Tedesco MA. Bricker SB, et al. Among authors: chintala m. Estuaries Coast. 2020 Jan 1;43:23-38. doi: 10.1007/s12237-019-00661-8. Estuaries Coast. 2020. PMID: 32021593 Free PMC article.
Structured Decision Making to Meet a National Water Quality Mandate.
Martin DM, Piscopo AN, Chintala MM, Gleason TR, Berry W. Martin DM, et al. Among authors: chintala mm. J Am Water Resour Assoc. 2019 Oct 1;55(5):1116-1129. doi: 10.1111/1752-1688.12754. J Am Water Resour Assoc. 2019. PMID: 33551634 Free PMC article.
68 results