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SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status.
Daley BR, Vieira HM, Rao C, Hughes JM, Beckley ZM, Huisman DH, Chatterjee D, Sealover NE, Cox K, Askew JW, Svoboda RA, Fisher KW, Lewis RE, Kortum RL. Daley BR, et al. Among authors: lewis re. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2313137120. doi: 10.1073/pnas.2313137120. Epub 2023 Nov 16. Proc Natl Acad Sci U S A. 2023. PMID: 37972068 Free PMC article.
The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis.
Kortum RL, Costanzo DL, Haferbier J, Schreiner SJ, Razidlo GL, Wu MH, Volle DJ, Mori T, Sakaue H, Chaika NV, Chaika OV, Lewis RE. Kortum RL, et al. Among authors: lewis re. Mol Cell Biol. 2005 Sep;25(17):7592-604. doi: 10.1128/MCB.25.17.7592-7604.2005. Mol Cell Biol. 2005. PMID: 16107706 Free PMC article.
KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.
Costanzo-Garvey DL, Pfluger PT, Dougherty MK, Stock JL, Boehm M, Chaika O, Fernandez MR, Fisher K, Kortum RL, Hong EG, Jun JY, Ko HJ, Schreiner A, Volle DJ, Treece T, Swift AL, Winer M, Chen D, Wu M, Leon LR, Shaw AS, McNeish J, Kim JK, Morrison DK, Tschöp MH, Lewis RE. Costanzo-Garvey DL, et al. Among authors: lewis re. Cell Metab. 2009 Nov;10(5):366-78. doi: 10.1016/j.cmet.2009.09.010. Cell Metab. 2009. PMID: 19883615 Free PMC article.
555 results