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Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation.
Kalailingam P, Mohd-Kahliab KH, Ngan SC, Iyappan R, Melekh E, Lu T, Zien GW, Sharma B, Guo T, MacNeil AJ, MacPherson RE, Tsiani EL, O'Leary DD, Lim KL, Su IH, Gao YG, Richards AM, Kalaria RN, Chen CP, McCarthy NE, Sze SK. Kalailingam P, et al. EMBO Mol Med. 2023 Dec 7;15(12):e18526. doi: 10.15252/emmm.202318526. Epub 2023 Nov 16. EMBO Mol Med. 2023. PMID: 37971164 Free PMC article.
Immunotherapeutic targeting of aging-associated isoDGR motif in chronic lung inflammation.
Kalailingam P, Ngan SC, Iyappan R, Nehchiri A, Mohd-Kahliab KH, Lee BST, Sharma B, Machan R, Bo ST, Chambers ES, Fajardo VA, Macpherson REK, Liu J, Klentrou P, Tsiani EL, Lim KL, Su IH, Gao YG, Richar AM, Kalaria RN, Chen CP, Balion C, de Kleijn D, McCarthy NE, Sze SK. Kalailingam P, et al. Aging Cell. 2025 Jan 5:e14425. doi: 10.1111/acel.14425. Online ahead of print. Aging Cell. 2025. PMID: 39757428 Free article.
In vivo Treatment of a Severe Vascular Disease via a Bespoke CRISPR-Cas9 Base Editor.
Alves CRR, Das S, Krishnan V, Ha LL, Fox LR, Stutzman HE, Shamber CE, Kalailingam P, McCarthy S, Lino Cardenas CL, Fong CE, Imai T, Mitra S, Yun S, Wood RK, Benning FMC, Lawton J, Kim N, Silverstein RA, da Silva JF, de la Cruz D, Richa R, Malhotra R, Chung DY, Chao LH, Tsai SQ, Maguire CA, Lindsay ME, Kleinstiver BP, Musolino PL. Alves CRR, et al. Among authors: kalailingam p. bioRxiv [Preprint]. 2024 Nov 11:2024.11.11.621817. doi: 10.1101/2024.11.11.621817. bioRxiv. 2024. PMID: 39605323 Free PMC article. Preprint.
13 results