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Modular vector assembly enables rapid assessment of emerging CRISPR technologies.
McGee AV, Liu YV, Griffith AL, Szegletes ZM, Wen B, Kraus C, Miller NW, Steger RJ, Velasco BE, Bosch JA, Zirin JD, Viswanatha R, Sontheimer EJ, Goodale A, Greene MA, Green TM, Doench JG. McGee AV, et al. Among authors: sontheimer ej. bioRxiv [Preprint]. 2023 Oct 27:2023.10.25.564061. doi: 10.1101/2023.10.25.564061. bioRxiv. 2023. Update in: Cell Genom. 2024 Mar 13;4(3):100519. doi: 10.1016/j.xgen.2024.100519 PMID: 37961518 Free PMC article. Updated. Preprint.
Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo.
Zhang H, Kelly K, Lee J, Echeverria D, Cooper D, Panwala R, Chen Z, Gaston N, Newby GA, Xie J, Liu DR, Gao G, Wolfe SA, Khvorova A, Watts JK, Sontheimer EJ. Zhang H, et al. Among authors: sontheimer ej. bioRxiv [Preprint]. 2023 Mar 23:2023.03.20.533459. doi: 10.1101/2023.03.20.533459. bioRxiv. 2023. Update in: Nucleic Acids Res. 2024 Jan 25;52(2):977-997. doi: 10.1093/nar/gkad1125 PMID: 36993169 Free PMC article. Updated. Preprint.
Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope.
Bamidele N, Zhang H, Dong X, Gaston N, Cheng H, Kelly K, Watts JK, Xie J, Gao G, Sontheimer EJ. Bamidele N, et al. Among authors: sontheimer ej. bioRxiv [Preprint]. 2023 Apr 18:2023.04.14.536905. doi: 10.1101/2023.04.14.536905. bioRxiv. 2023. Update in: Nat Commun. 2024 Feb 17;15(1):1458. doi: 10.1038/s41467-024-45763-5 PMID: 37131611 Free PMC article. Updated. Preprint.
Modular vector assembly enables rapid assessment of emerging CRISPR technologies.
McGee AV, Liu YV, Griffith AL, Szegletes ZM, Wen B, Kraus C, Miller NW, Steger RJ, Escude Velasco B, Bosch JA, Zirin JD, Viswanatha R, Sontheimer EJ, Goodale A, Greene MA, Green TM, Doench JG. McGee AV, et al. Among authors: sontheimer ej. Cell Genom. 2024 Mar 13;4(3):100519. doi: 10.1016/j.xgen.2024.100519. Cell Genom. 2024. PMID: 38484704 Free PMC article.
Increasing intracellular dNTP levels improves prime editing efficiency.
Liu P, Ponnienselvan K, Nyalile T, Oikemus S, Joynt AT, Iyer S, Kelly K, Guo D, Kyawe PP, Vanderleeden E, Redick SD, Huang L, Chen Z, Lee JM, Schiffer CA, Harlan DM, Wang JP, Emerson CP Jr, Lawson ND, Watts JK, Sontheimer EJ, Luban J, Wolfe SA. Liu P, et al. Among authors: sontheimer ej. Nat Biotechnol. 2024 Sep 25. doi: 10.1038/s41587-024-02405-x. Online ahead of print. Nat Biotechnol. 2024. PMID: 39322763
Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo.
Zhang H, Kelly K, Lee J, Echeverria D, Cooper D, Panwala R, Amrani N, Chen Z, Gaston N, Wagh A, Newby GA, Xie J, Liu DR, Gao G, Wolfe SA, Khvorova A, Watts JK, Sontheimer EJ. Zhang H, et al. Among authors: sontheimer ej. Nucleic Acids Res. 2024 Jan 25;52(2):977-997. doi: 10.1093/nar/gkad1125. Nucleic Acids Res. 2024. PMID: 38033325 Free PMC article.
115 results