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63 results

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Page 1
Missense mutations in Myc Box I influence MYC cellular localization, mRNA partitioning and turnover to promote leukemogenesis.
Arthur NB, Christensen KA, Mannino K, Ruzinova MB, Kumar A, Gruszczynska A, Day RB, Erdmann-Gilmore P, Mi Y, Sprung R, York CR, Reid Townsend R, Spencer DH, Sykes SM, Ferraro F. Arthur NB, et al. Among authors: spencer dh. bioRxiv [Preprint]. 2023 Oct 23:2023.10.22.563493. doi: 10.1101/2023.10.22.563493. bioRxiv. 2023. Update in: Clin Cancer Res. 2024 Aug 15;30(16):3622-3639. doi: 10.1158/1078-0432.CCR-24-0926. PMID: 37961226 Free PMC article. Updated. Preprint.
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.
Russler-Germain DA, Spencer DH, Young MA, Lamprecht TL, Miller CA, Fulton R, Meyer MR, Erdmann-Gilmore P, Townsend RR, Wilson RK, Ley TJ. Russler-Germain DA, et al. Among authors: spencer dh. Cancer Cell. 2014 Apr 14;25(4):442-54. doi: 10.1016/j.ccr.2014.02.010. Epub 2014 Mar 20. Cancer Cell. 2014. PMID: 24656771 Free PMC article.
Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes.
Ferraro F, Miller CA, Christensen KA, Helton NM, O'Laughlin M, Fronick CC, Fulton RS, Kohlschmidt J, Eisfeld AK, Bloomfield CD, Ramakrishnan SM, Day RB, Wartman LD, Uy GL, Welch JS, Christopher MJ, Heath SE, Baty JD, Schuelke MJ, Payton JE, Spencer DH, Rettig MP, Link DC, Walter MJ, Westervelt P, DiPersio JF, Ley TJ. Ferraro F, et al. Among authors: spencer dh. Proc Natl Acad Sci U S A. 2021 Dec 7;118(49):e2116427118. doi: 10.1073/pnas.2116427118. Proc Natl Acad Sci U S A. 2021. PMID: 34845035 Free PMC article.
Genomic landscape of TP53 -mutated myeloid malignancies.
Abel HJ, Oetjen KA, Miller CA, Ramakrishnan SM, Day RB, Helton NM, Fronick CC, Fulton RS, Heath SE, Tarnawsky SP, Srivatsan SN, Duncavage EJ, Schroeder MC, Payton JE, Spencer DH, Walter MJ, Westervelt P, DiPersio JF, Ley TJ, Link DC. Abel HJ, et al. Among authors: spencer dh. medRxiv [Preprint]. 2023 Jan 11:2023.01.10.23284322. doi: 10.1101/2023.01.10.23284322. medRxiv. 2023. Update in: Blood Adv. 2023 Aug 22;7(16):4586-4598. doi: 10.1182/bloodadvances.2023010156. PMID: 36711871 Free PMC article. Updated. Preprint.
Genomic impact of transient low-dose decitabine treatment on primary AML cells.
Klco JM, Spencer DH, Lamprecht TL, Sarkaria SM, Wylie T, Magrini V, Hundal J, Walker J, Varghese N, Erdmann-Gilmore P, Lichti CF, Meyer MR, Townsend RR, Wilson RK, Mardis ER, Ley TJ. Klco JM, et al. Among authors: spencer dh. Blood. 2013 Feb 28;121(9):1633-43. doi: 10.1182/blood-2012-09-459313. Epub 2013 Jan 7. Blood. 2013. PMID: 23297133 Free PMC article.
Genomic landscape of TP53-mutated myeloid malignancies.
Abel HJ, Oetjen KA, Miller CA, Ramakrishnan SM, Day RB, Helton NM, Fronick CC, Fulton RS, Heath SE, Tarnawsky SP, Nonavinkere Srivatsan S, Duncavage EJ, Schroeder MC, Payton JE, Spencer DH, Walter MJ, Westervelt P, DiPersio JF, Ley TJ, Link DC. Abel HJ, et al. Among authors: spencer dh. Blood Adv. 2023 Aug 22;7(16):4586-4598. doi: 10.1182/bloodadvances.2023010156. Blood Adv. 2023. PMID: 37339484 Free PMC article.
Molecular responses in decitabine- and decitabine/ venetoclax-treated patients with acute myeloid leukemia and myelodysplastic syndromes.
Gruszczynska A, Maiti A, Miller CA, Ramakrishnan SM, Link DC, Uy GL, Petti AA, Hayes K, DiNardo CD, Ravandi F, Ley TJ, Spencer DH, Gao F, Konopleva MY, Welch JS. Gruszczynska A, et al. Among authors: spencer dh. Haematologica. 2024 Aug 1;109(8):2653-2659. doi: 10.3324/haematol.2022.281396. Haematologica. 2024. PMID: 38618679 Free PMC article. No abstract available.
Regulatory Considerations for Genome-Edited T-cell Therapies.
Jadlowsky JK, Chang JF, Spencer DH, Warrington JM, Levine BL, June CH, Fraietta JA, Singh N. Jadlowsky JK, et al. Among authors: spencer dh. Cancer Immunol Res. 2024 Sep 3;12(9):1132-1135. doi: 10.1158/2326-6066.CIR-24-0482. Cancer Immunol Res. 2024. PMID: 39018097 Review.
Clinical whole-genome sequencing and FISH identify two different fusion partners for NUP98 in a patient with acute myeloid leukemia: A case report.
Mojarad BA, Crees ZD, Schroeder MC, Xiang Z, Vader J, Sina J, Jacoby M, Frater JL, Duncavage EJ, Spencer DH, Lavine K, Neidich JA, Amarillo I. Mojarad BA, et al. Among authors: spencer dh. Cancer Genet. 2024 Jan;280-281:1-5. doi: 10.1016/j.cancergen.2023.11.001. Epub 2023 Nov 29. Cancer Genet. 2024. PMID: 38056049
63 results