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Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation.
Que Z, Olivero-Acosta MI, Chen I, Zhang J, Wettschurack K, Wu J, Xiao T, Otterbacher CM, Wang M, Harlow H, Cui N, Chen X, Deming B, Halurkar M, Zhao Y, Rochet JC, Xu R, Brewster AL, Wu LJ, Yuan C, Skarnes WC, Yang Y. Que Z, et al. Among authors: yang y. bioRxiv [Preprint]. 2023 Oct 31:2023.10.26.563426. doi: 10.1101/2023.10.26.563426. bioRxiv. 2023. Update in: J Neurosci. 2024 Nov 18:e2027232024. doi: 10.1523/JNEUROSCI.2027-23.2024 PMID: 37961213 Free PMC article. Updated. Preprint.
Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant.
Que Z, Olivero-Acosta MI, Zhang J, Eaton M, Tukker AM, Chen X, Wu J, Xie J, Xiao T, Wettschurack K, Yunis L, Shafer JM, Schaber JA, Rochet JC, Bowman AB, Yuan C, Huang Z, Hu CD, Trader DJ, Skarnes WC, Yang Y. Que Z, et al. Among authors: yang y. J Neurosci. 2021 Dec 8;41(49):10194-10208. doi: 10.1523/JNEUROSCI.0564-21.2021. Epub 2021 Oct 29. J Neurosci. 2021. PMID: 34716231 Free PMC article.
Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids.
Yang Y, Wu J, Zhang J, Chen X, Que Z, Wettschurack K, Deming B, Acosta M, Cui N, Eaton M, Zhao Y, Halurkar M, Purba M, Chen I, Xiao T, Suzuki M, Yuan C, Xu R, Koss W, Du D, Chen F, Wu LJ, Clinic M. Yang Y, et al. Res Sq [Preprint]. 2023 Sep 28:rs.3.rs-3270664. doi: 10.21203/rs.3.rs-3270664/v1. Res Sq. 2023. Update in: Mol Psychiatry. 2024 Aug;29(8):2424-2437. doi: 10.1038/s41380-024-02518-4 PMID: 37841865 Free PMC article. Updated. Preprint.
Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids.
Wu J, Zhang J, Chen X, Wettschurack K, Que Z, Deming BA, Olivero-Acosta MI, Cui N, Eaton M, Zhao Y, Li SM, Suzuki M, Chen I, Xiao T, Halurkar MS, Mandal P, Yuan C, Xu R, Koss WA, Du D, Chen F, Wu LJ, Yang Y. Wu J, et al. Among authors: yang y. Mol Psychiatry. 2024 Aug;29(8):2424-2437. doi: 10.1038/s41380-024-02518-4. Epub 2024 Mar 18. Mol Psychiatry. 2024. PMID: 38499656
Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation.
Que Z, Olivero-Acosta MI, Robinson M, Chen I, Zhang J, Wettschurack K, Wu J, Xiao T, Otterbacher CM, Shankar V, Harlow H, Hong S, Zirkle B, Wang M, Cui N, Mandal P, Chen X, Deming B, Halurkar M, Zhao Y, Rochet JC, Xu R, Brewster AL, Wu LJ, Yuan C, Skarnes WC, Yang Y. Que Z, et al. Among authors: yang y. J Neurosci. 2024 Nov 18:e2027232024. doi: 10.1523/JNEUROSCI.2027-23.2024. Online ahead of print. J Neurosci. 2024. PMID: 39557580
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