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Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross-stage recognition of glutamate-rich repeats.
Amen A, Yoo R, Fabra-García A, Bolscher J, Stone WJR, Bally I, Dergan-Dylon S, Kucharska I, de Jong RM, de Bruijni M, Bousema T, King CR, MacGill RS, Sauerwein RW, Julien JP, Poignard P, Jore MM. Amen A, et al. Among authors: sauerwein rw. Elife. 2025 Jan 16;13:RP97865. doi: 10.7554/eLife.97865. Elife. 2025. PMID: 39817720 Free PMC article.
A Pfs48/45-based vaccine to block Plasmodium falciparum transmission: phase 1, open-label, clinical trial.
Alkema M, Smit MJ, Marin-Mogollon C, Totté K, Teelen K, van Gemert GJ, van de Vegte-Bolmer M, Mordmüller BG, Reimer JM, Lövgren-Bengtsson KL, Sauerwein RW, Bousema T, Plieskatt J, Theisen M, Jore MM, McCall MBB. Alkema M, et al. Among authors: sauerwein rw. BMC Med. 2024 Apr 23;22(1):170. doi: 10.1186/s12916-024-03379-y. BMC Med. 2024. PMID: 38649867 Free PMC article. Clinical Trial.
Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross stage recognition of glutamate-rich repeats.
Amen A, Yoo R, Fabra-García A, Bolscher J, Stone WJR, Bally I, Dergan-Dylon S, Kucharska I, de Jong RM, de Bruijni M, Bousema T, Richter King C, MacGill RS, Sauerwein RW, Julien JP, Poignard P, Jore MM. Amen A, et al. Among authors: sauerwein rw. bioRxiv [Preprint]. 2024 Jul 2:2023.11.03.565335. doi: 10.1101/2023.11.03.565335. bioRxiv. 2024. Update in: Elife. 2025 Jan 16;13:RP97865. doi: 10.7554/eLife.97865 PMID: 37961136 Free PMC article. Updated. Preprint.
Sporozoite immunization: innovative translational science to support the fight against malaria.
Richie TL, Church LWP, Murshedkar T, Billingsley PF, James ER, Chen MC, Abebe Y, Natasha Kc, Chakravarty S, Dolberg D, Healy SA, Diawara H, Sissoko MS, Sagara I, Cook DM, Epstein JE, Mordmüller B, Kapulu M, Kreidenweiss A, Franke-Fayard B, Agnandji ST, López Mikue MA, McCall MBB, Steinhardt L, Oneko M, Olotu A, Vaughan AM, Kublin JG, Murphy SC, Jongo S, Tanner M, Sirima SB, Laurens MB, Daubenberger C, Silva JC, Lyke KE, Janse CJ, Roestenberg M, Sauerwein RW, Abdulla S, Dicko A, Kappe SHI, Sim BKL, Duffy PE, Kremsner PG, Hoffman SL. Richie TL, et al. Among authors: sauerwein rw. Expert Rev Vaccines. 2023 Jan-Dec;22(1):964-1007. doi: 10.1080/14760584.2023.2245890. Epub 2023 Aug 11. Expert Rev Vaccines. 2023. PMID: 37571809 Free PMC article. Review.
Development of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid cultures.
Yang ASP, Dutta D, Kretzschmar K, Hendriks D, Puschhof J, Hu H, Boonekamp KE, van Waardenburg Y, Chuva de Sousa Lopes SM, van Gemert GJ, de Wilt JHW, Bousema T, Clevers H, Sauerwein RW. Yang ASP, et al. Among authors: sauerwein rw. Nat Commun. 2023 Aug 2;14(1):4631. doi: 10.1038/s41467-023-40298-7. Nat Commun. 2023. PMID: 37532704 Free PMC article.
The decrease in plasma cholesterol during Plasmodium falciparum infections is not caused by cholesterol utilization by the parasites but by an infection-induced acute-phase response.
Vliegenthart-Jongbloed KJ, Koelewijn R, Tielens AGM, Sauerwein RW, van Hellemond JJ, van Genderen PJJ. Vliegenthart-Jongbloed KJ, et al. Among authors: sauerwein rw. J Infect. 2023 Jun;86(6):617-619. doi: 10.1016/j.jinf.2023.02.031. Epub 2023 Mar 2. J Infect. 2023. PMID: 36868319 No abstract available.
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230.
Ivanochko D, Fabra-García A, Teelen K, van de Vegte-Bolmer M, van Gemert GJ, Newton J, Semesi A, de Bruijni M, Bolscher J, Ramjith J, Szabat M, Vogt S, Kraft L, Duncan S, Lee SM, Kamya MR, Feeney ME, Jagannathan P, Greenhouse B, Sauerwein RW, Richter King C, MacGill RS, Bousema T, Jore MM, Julien JP. Ivanochko D, et al. Among authors: sauerwein rw. Immunity. 2023 Feb 14;56(2):420-432.e7. doi: 10.1016/j.immuni.2023.01.013. Immunity. 2023. PMID: 36792575 Free PMC article.
312 results