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Multi-modal skin atlas identifies a multicellular immune-stromal community associated with altered cornification and specific T cell expansion in atopic dermatitis.
Fiskin E, Eraslan G, Alora-Palli MB, Leyva-Castillo JM, Kim S, Choe H, Lareau CA, Lau H, Finan EP, Teixeira-Soldano I, LaBere B, Chu A, Woods B, Chou J, Slyper M, Waldman J, Islam S, Schneider L, Phipatanakul W, Platt C, Rozenblatt-Rosen O, Delorey TM, Deguine J, Smith GP, Geha R, Regev A, Xavier R. Fiskin E, et al. Among authors: leyva castillo jm. bioRxiv [Preprint]. 2023 Oct 31:2023.10.29.563503. doi: 10.1101/2023.10.29.563503. bioRxiv. 2023. PMID: 37961084 Free PMC article. Preprint.
Basophil: The cell that itches.
Das M, Leyva-Castillo JM, Geha RS. Das M, et al. J Allergy Clin Immunol. 2021 Sep;148(3):708-709. doi: 10.1016/j.jaci.2021.06.010. Epub 2021 Jun 17. J Allergy Clin Immunol. 2021. PMID: 34147536 No abstract available.
The IL-4Rα Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice.
Yang B, Wilkie H, Das M, Timilshina M, Bainter W, Woods B, Daya M, Boorgula MP, Mathias RA, Lai P, Petty CR, Weller E, Harb H, Chatila TA, Leung DYM, Beck LA, Simpson EL, Hata TR, Barnes KC, Phipatanakul W, Leyva-Castillo JM, Geha RS. Yang B, et al. J Allergy Clin Immunol. 2023 May;151(5):1296-1306.e7. doi: 10.1016/j.jaci.2023.01.011. Epub 2023 Jan 21. J Allergy Clin Immunol. 2023. PMID: 36690254 Free PMC article.
Basophils are important for development of allergic skin inflammation.
Leyva-Castillo JM, Vega-Mendoza D, Strakosha M, Deng L, Choi S, Miyake K, Karasuyama H, Chiu IM, Phipatanakul W, Geha RS. Leyva-Castillo JM, et al. J Allergy Clin Immunol. 2024 May;153(5):1344-1354.e5. doi: 10.1016/j.jaci.2024.01.022. Epub 2024 Feb 7. J Allergy Clin Immunol. 2024. PMID: 38336257
35 results