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IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial.
Ackerman L, Acloque G, Bacchelli S, Schwartz H, Feinstein BJ, La Stella P, Alavi A, Gollerkeri A, Davis J, Campbell V, McDonald A, Agarwal S, Karnik R, Shi K, Mishkin A, Culbertson J, Klaus C, Enerson B, Massa V, Kuhn E, Sharma K, Keaney E, Barnes R, Chen D, Zheng X, Rong H, Sabesan V, Ho C, Mainolfi N, Slavin A, Gollob JA. Ackerman L, et al. Among authors: sharma k. Nat Med. 2023 Dec;29(12):3127-3136. doi: 10.1038/s41591-023-02635-7. Epub 2023 Nov 13. Nat Med. 2023. PMID: 37957373 Free PMC article. Clinical Trial.
Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma.
Weiss MM, Zheng X, Ji N, Browne CM, Campbell V, Chen D, Enerson B, Fei X, Huang X, Klaus CR, Li H, Mayo M, McDonald AA, Paul A, Rong H, Sharma K, Shi Y, Slavin A, Walther DM, Yuan K, Zhang Y, Zhu X, Kelleher J, Walker D, Mainolfi N. Weiss MM, et al. Among authors: sharma k. J Med Chem. 2024 Jul 11;67(13):10548-10566. doi: 10.1021/acs.jmedchem.3c01823. Epub 2024 Jun 26. J Med Chem. 2024. PMID: 38920289
Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases.
Zheng X, Ji N, Campbell V, Slavin A, Zhu X, Chen D, Rong H, Enerson B, Mayo M, Sharma K, Browne CM, Klaus CR, Li H, Massa G, McDonald AA, Shi Y, Sintchak M, Skouras S, Walther DM, Yuan K, Zhang Y, Kelleher J, Liu G, Luo X, Mainolfi N, Weiss MM. Zheng X, et al. Among authors: sharma k. J Med Chem. 2024 Oct 24;67(20):18022-18037. doi: 10.1021/acs.jmedchem.4c01305. Epub 2024 Aug 16. J Med Chem. 2024. PMID: 39151120 Free PMC article. Clinical Trial.
Acceptability of Mifepristone and Misoprostol and Patients' Experience with the Early Pregnancy Assessment Clinic at a Community Hospital in Canada.
Farooqi S, Lackie E, Pham A, Zolis L, Sharma K, Devarajan K, Smith K, Nevin-Lam A, Lee S, Tempest H, Mei-Dan E, Tunde-Byass M. Farooqi S, et al. Among authors: sharma k. J Obstet Gynaecol Can. 2025 Jan 22:102771. doi: 10.1016/j.jogc.2025.102771. Online ahead of print. J Obstet Gynaecol Can. 2025. PMID: 39855394
Ethnic and racial differences in children and young people with respiratory and neurological post-acute sequelae of SARS-CoV-2: an electronic health record-based cohort study from the RECOVER Initiative.
Rao S, Azuero-Dajud R, Lorman V, Landeo-Gutierrez J, Rhee KE, Ryu J, Kim C, Carmilani M, Gross RS, Mohandas S, Suresh S, Bailey LC, Castro V, Senathirajah Y, Esquenazi-Karonika S, Murphy S, Caddle S, Kleinman LC, Castro-Baucom L, Oliveira CR, Klein JD, Chung A, Cowell LG, Madlock-Brown C, Geary CR, Sills MR, Thorpe LE, Szmuszkovicz J, Tantisira KG; RECOVER EHR and; RECOVER Pediatric Cohorts. Rao S, et al. EClinicalMedicine. 2025 Jan 2;80:103042. doi: 10.1016/j.eclinm.2024.103042. eCollection 2025 Feb. EClinicalMedicine. 2025. PMID: 39850015 Free PMC article.
4,940 results