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High-Throughput Analyses of Therapeutic Antibodies Using High-Field Asymmetric Waveform Ion Mobility Spectrometry Combined with SampleStream and Intact Protein Mass Spectrometry.
Shi RL, Dillon MA, Compton PD, Sawyer WS, Thorup JR, Kwong M, Chan P, Chiu CPC, Li R, Yadav R, Lee GY, Gober JG, Li Z, ElSohly AM, Ovacik AM, Koerber JT, Spiess C, Josephs JL, Tran JC. Shi RL, et al. Among authors: chan p. Anal Chem. 2023 Nov 28;95(47):17263-17272. doi: 10.1021/acs.analchem.3c03158. Epub 2023 Nov 13. Anal Chem. 2023. PMID: 37956201
Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model.
Meilandt WJ, Ngu H, Gogineni A, Lalehzadeh G, Lee SH, Srinivasan K, Imperio J, Wu T, Weber M, Kruse AJ, Stark KL, Chan P, Kwong M, Modrusan Z, Friedman BA, Elstrott J, Foreman O, Easton A, Sheng M, Hansen DV. Meilandt WJ, et al. Among authors: chan p. J Neurosci. 2020 Feb 26;40(9):1956-1974. doi: 10.1523/JNEUROSCI.1871-19.2019. Epub 2020 Jan 24. J Neurosci. 2020. PMID: 31980586 Free PMC article.
Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response.
Dela Cruz Chuh J, Go M, Chen Y, Guo J, Rafidi H, Mandikian D, Sun Y, Lin Z, Schneider K, Zhang P, Vij R, Sharpnack D, Chan P, de la Cruz C, Sadowsky J, Seshasayee D, Koerber JT, Pillow TH, Phillips GD, Rowntree RK, Boswell CA, Kozak KR, Polson AG, Polakis P, Yu SF, Dragovich PS, Agard NJ. Dela Cruz Chuh J, et al. Among authors: chan p. MAbs. 2021 Jan-Dec;13(1):1862452. doi: 10.1080/19420862.2020.1862452. MAbs. 2021. PMID: 33382956 Free PMC article.
Direct Tie2 Agonists Stabilize Vasculature for the Treatment of Diabetic Macular Edema.
Agard NJ, Zhang G, Ridgeway J, Dicara DM, Chu PY, Ohri R, Sanowar S, Vernes JM, Chi H, Zhang J, Holz E, Paluch M, He G, Benson Y, Zhang J, Chan P, Tang N, Javale P, Wilson B, Barrett K, Rowntree RK, Hang J, Meng YG, Hass P, Fuh G, Piskol R, Bantseev V, Loyet KM, Tran JC, Wu C, Indjeian VB, Shivva V, Yan M. Agard NJ, et al. Among authors: chan p. Transl Vis Sci Technol. 2022 Oct 3;11(10):27. doi: 10.1167/tvst.11.10.27. Transl Vis Sci Technol. 2022. PMID: 36255358 Free PMC article.
Mini-PBPK-Based Population Model and Covariate Analysis to Assess the Complex Pharmacokinetics and Pharmacodynamics of RO7449135, an Anti-KLK5/KLK7 Bispecific Antibody in Cynomolgus Monkeys.
Cai H, Tao X, Shim J, Bauer RN, Bremer M, Bu W, LaMar J, Basile R, Dere E, Nguyen T, Laing S, Chan P, Yi T, Koerber JT, Sperinde G, Stefanich E. Cai H, et al. Among authors: chan p. AAPS J. 2023 Jun 23;25(4):64. doi: 10.1208/s12248-023-00829-y. AAPS J. 2023. PMID: 37353723
A strategy for risk mitigation of antibodies with fast clearance.
Hötzel I, Theil FP, Bernstein LJ, Prabhu S, Deng R, Quintana L, Lutman J, Sibia R, Chan P, Bumbaca D, Fielder P, Carter PJ, Kelley RF. Hötzel I, et al. Among authors: chan p. MAbs. 2012 Nov-Dec;4(6):753-60. doi: 10.4161/mabs.22189. MAbs. 2012. PMID: 23778268 Free PMC article.
5,520 results