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Enhanced Mitochondrial Targeting and Inhibition of Pyroptosis with Multifunctional Metallopolyphenol Nanoparticles in Intervertebral Disc Degeneration.
Zhou H, Qian Q, Chen Q, Chen T, Wu C, Chen L, Zhang Z, Wu O, Jin Y, Wang X, Guo Z, Sun J, Zhang J, Shen S, Wang X, Jones M, Khan MA, Makvandi P, Zhou Y, Wu A. Zhou H, et al. Among authors: chen l, chen q, chen t. Small. 2024 Mar;20(13):e2308167. doi: 10.1002/smll.202308167. Epub 2023 Nov 12. Small. 2024. PMID: 37953455
Engineered high-strength biohydrogel as a multifunctional platform to deliver nucleic acid for ameliorating intervertebral disc degeneration.
Chen T, Qian Q, Makvandi P, Zare EN, Chen Q, Chen L, Zhang Z, Zhou H, Zhou W, Wang H, Wang X, Chen Y, Zhou Y, Wu A. Chen T, et al. Among authors: chen l, chen q, chen y. Bioact Mater. 2023 Jan 31;25:107-121. doi: 10.1016/j.bioactmat.2023.01.010. eCollection 2023 Jul. Bioact Mater. 2023. PMID: 37056255 Free PMC article.
Mitochondrial-Targeted Metal-Phenolic Nanoparticles to Attenuate Intervertebral Disc Degeneration: Alleviating Oxidative Stress and Mitochondrial Dysfunction.
Chen Q, Qian Q, Xu H, Zhou H, Chen L, Shao N, Zhang K, Chen T, Tian H, Zhang Z, Jones M, Kwan KYH, Sewell M, Shen S, Wang X, Khan MA, Makvandi P, Jin S, Zhou Y, Wu A. Chen Q, et al. Among authors: chen l, chen t. ACS Nano. 2024 Mar 26;18(12):8885-8905. doi: 10.1021/acsnano.3c12163. Epub 2024 Mar 11. ACS Nano. 2024. PMID: 38465890
Hypoxia-Preconditioned BMSC-Derived Exosomes Induce Mitophagy via the BNIP3-ANAX2 Axis to Alleviate Intervertebral Disc Degeneration.
Jin Y, Wu O, Chen Q, Chen L, Zhang Z, Tian H, Zhou H, Zhang K, Gao J, Wang X, Guo Z, Sun J, Kwan KYH, Jones M, Li YM, Zare EN, Makvandi P, Wang X, Shen S, Wu A. Jin Y, et al. Among authors: chen l, chen q. Adv Sci (Weinh). 2024 Sep;11(34):e2404275. doi: 10.1002/advs.202404275. Epub 2024 Jul 8. Adv Sci (Weinh). 2024. PMID: 38973294 Free PMC article.
Role of oxidative stress in mitochondrial dysfunction and their implications in intervertebral disc degeneration: Mechanisms and therapeutic strategies.
Zhou H, Wu C, Jin Y, Wu O, Chen L, Guo Z, Wang X, Chen Q, Kwan KYH, Li YM, Xia D, Chen T, Wu A. Zhou H, et al. Among authors: chen l, chen q, chen t. J Orthop Translat. 2024 Oct 16;49:181-206. doi: 10.1016/j.jot.2024.08.016. eCollection 2024 Nov. J Orthop Translat. 2024. PMID: 39483126 Free PMC article. Review.
KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression.
Wu O, Jin Y, Zhang Z, Zhou H, Xu W, Chen L, Jones M, Kwan KYH, Gao J, Zhang K, Cheng X, Chen Q, Wang X, Li YM, Guo Z, Sun J, Chen Z, Wang B, Wang X, Shen S, Wu A. Wu O, et al. Among authors: chen z, chen l, chen q. Bone Res. 2024 Nov 21;12(1):67. doi: 10.1038/s41413-024-00373-1. Bone Res. 2024. PMID: 39572532 Free PMC article.
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