Xu H - Search Results

1

CRISPR-Cas9-based functional interrogation of unconventional translatome reveals human cancer dependency on cryptic non-canonical open reading frames.

Zheng C, Wei Y, Zhang P, Lin K, He D, Teng H, Manyam G, Zhang Z, Liu W, Lee HRL, Tang X, He W, Islam N, Jain A, Chiu Y, Cao S, Diao Y, Meyer-Gauen S, Höök M, Malovannaya A, Li W, Hu M, Wang W, Xu H, Kopetz S, Chen Y. Zheng C, et al. Among authors: xu h. Nat Struct Mol Biol. 2023 Dec;30(12):1878-1892. doi: 10.1038/s41594-023-01117-1. Epub 2023 Nov 6. Nat Struct Mol Biol. 2023. PMID: 37932451 Free PMC article.

2

CRISPR/Cas9 screen uncovers functional translation of cryptic lncRNA-encoded open reading frames in human cancer.

Zheng C, Wei Y, Zhang P, Xu L, Zhang Z, Lin K, Hou J, Lv X, Ding Y, Chiu Y, Jain A, Islam N, Malovannaya A, Wu Y, Ding F, Xu H, Sun M, Chen X, Chen Y. Zheng C, et al. Among authors: xu l, xu h. J Clin Invest. 2023 Mar 1;133(5):e159940. doi: 10.1172/JCI159940. J Clin Invest. 2023. PMID: 36856111 Free PMC article.

3

Systematic functional interrogation of human pseudogenes using CRISPRi.

Sun M, Wang Y, Zheng C, Wei Y, Hou J, Zhang P, He W, Lv X, Ding Y, Liang H, Hon CC, Chen X, Xu H, Chen Y. Sun M, et al. Among authors: xu h. Genome Biol. 2021 Aug 23;22(1):240. doi: 10.1186/s13059-021-02464-2. Genome Biol. 2021. PMID: 34425866 Free PMC article.

4

GuidePro: a multi-source ensemble predictor for prioritizing sgRNAs in CRISPR/Cas9 protein knockouts.

He W, Wang H, Wei Y, Jiang Z, Tang Y, Chen Y, Xu H. He W, et al. Among authors: xu h. Bioinformatics. 2021 Apr 9;37(1):134-136. doi: 10.1093/bioinformatics/btaa1068. Bioinformatics. 2021. PMID: 33394026 Free PMC article.

5

Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity.

Fu R, He W, Dou J, Villarreal OD, Bedford E, Wang H, Hou C, Zhang L, Wang Y, Ma D, Chen Y, Gao X, Depken M, Xu H. Fu R, et al. Among authors: xu h. Nat Commun. 2022 Jan 25;13(1):474. doi: 10.1038/s41467-022-28028-x. Nat Commun. 2022. PMID: 35078987 Free PMC article.

6

Guide-specific loss of efficiency and off-target reduction with Cas9 variants.

Zhang L, He W, Fu R, Wang S, Chen Y, Xu H. Zhang L, et al. Among authors: xu h. Nucleic Acids Res. 2023 Oct 13;51(18):9880-9893. doi: 10.1093/nar/gkad702. Nucleic Acids Res. 2023. PMID: 37615574 Free PMC article.

7

Multiomics analyses reveal DARS1-AS1/YBX1-controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance.

Zheng C, Wei Y, Zhang Q, Sun M, Wang Y, Hou J, Zhang P, Lv X, Su D, Jiang Y, Gumin J, Sahni N, Hu B, Wang W, Chen X, McGrail DJ, Zhang C, Huang S, Xu H, Chen J, Lang FF, Hu J, Chen Y. Zheng C, et al. Among authors: xu h. Sci Adv. 2023 Aug 4;9(31):eadf3984. doi: 10.1126/sciadv.adf3984. Epub 2023 Aug 4. Sci Adv. 2023. PMID: 37540752 Free PMC article.

8

De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens.

He W, Zhang L, Villarreal OD, Fu R, Bedford E, Dou J, Patel AY, Bedford MT, Shi X, Chen T, Bartholomew B, Xu H. He W, et al. Among authors: xu h. Nat Commun. 2019 Oct 4;10(1):4541. doi: 10.1038/s41467-019-12489-8. Nat Commun. 2019. PMID: 31586052 Free PMC article.

9

TAZ2 truncation confers overactivation of p300 and cellular vulnerability to HDAC inhibition.

Xu L, Xuan H, He W, Zhang L, Huang M, Li K, Wen H, Xu H, Shi X. Xu L, et al. Among authors: xu h. Nat Commun. 2023 Sep 2;14(1):5362. doi: 10.1038/s41467-023-41245-2. Nat Commun. 2023. PMID: 37660055 Free PMC article.

10

Author Correction: De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens.

He W, Zhang L, Villarreal OD, Fu R, Bedford E, Dou J, Patel AY, Bedford MT, Shi X, Chen T, Bartholomew B, Xu H. He W, et al. Among authors: xu h. Nat Commun. 2020 Feb 25;11(1):1134. doi: 10.1038/s41467-020-14940-7. Nat Commun. 2020. PMID: 32098955 Free PMC article.

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