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Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells.
Abdelsalam M, Zmyslia M, Schmidtkunz K, Vecchio A, Hilscher S, Ibrahim HS, Schutkowski M, Jung M, Jessen-Trefzer C, Sippl W. Abdelsalam M, et al. Among authors: ibrahim hs. Arch Pharm (Weinheim). 2024 Feb;357(2):e2300536. doi: 10.1002/ardp.202300536. Epub 2023 Nov 6. Arch Pharm (Weinheim). 2024. PMID: 37932028
Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity.
Ibrahim HS, Abdelsalam M, Zeyn Y, Zessin M, Mustafa AM, Fischer MA, Zeyen P, Sun P, Bülbül EF, Vecchio A, Erdmann F, Schmidt M, Robaa D, Barinka C, Romier C, Schutkowski M, Krämer OH, Sippl W. Ibrahim HS, et al. Int J Mol Sci. 2021 Dec 29;23(1):369. doi: 10.3390/ijms23010369. Int J Mol Sci. 2021. PMID: 35008795 Free PMC article.
Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells.
Fischer MA, Mustafa AM, Hausmann K, Ashry R, Kansy AG, Liebl MC, Brachetti C, Piée-Staffa A, Zessin M, Ibrahim HS, Hofmann TG, Schutkowski M, Sippl W, Krämer OH. Fischer MA, et al. Among authors: ibrahim hs. J Adv Res. 2024 Jun;60:201-214. doi: 10.1016/j.jare.2023.07.005. Epub 2023 Jul 17. J Adv Res. 2024. PMID: 37467961 Free PMC article.
115 results