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Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3' End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute-2 PAZ Domain.
Das RS, Datta D, Brown CR, Gilbert JA, Chan A, Willoughby J, Gupta S, Kim M, Degaonkar R, Racie T, Lei L, Schlegel MK, Castoreno A, Charisse K, Rajeev KG, Egli M, Manoharan M. Das RS, et al. Among authors: brown cr. J Med Chem. 2025 Feb 3. doi: 10.1021/acs.jmedchem.4c02250. Online ahead of print. J Med Chem. 2025. PMID: 39899704
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