Garcia-Ocaña A - Search Results

1

Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant.

Yammine L, Picatoste B, Abdullah N, Leahey RA, Johnson EF, Gómez-Banoy N, Rosselot C, Wen J, Hossain T, Goncalves MD, Lo JC, Garcia-Ocaña A, McGraw TE. Yammine L, et al. Mol Metab. 2023 Dec;78:101831. doi: 10.1016/j.molmet.2023.101831. Epub 2023 Nov 2. Mol Metab. 2023. PMID: 37925022 Free PMC article.

2

Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes.

Katz LS, Brill G, Wang P, Lambertini L, Zhang P, Haldeman JM, Liu H, Newgard CB, Stewart AF, Garcia-Ocaña A, Scott DK. Katz LS, et al. Among authors: garcia ocana a. Mol Metab. 2024 Jan;79:101848. doi: 10.1016/j.molmet.2023.101848. Epub 2023 Nov 30. Mol Metab. 2024. PMID: 38042369 Free PMC article.

3

LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK.

Filipowska J, Cisneros Z, Varghese SS, Leon-Rivera N, Wang P, Kang R, Lu G, Yuan YC, Shih HP, Bhattacharya S, Dhawan S, Garcia-Ocaña A, Kondegowda NG, Vasavada RC. Filipowska J, et al. Among authors: garcia ocana a. Mol Metab. 2025 Jan 7;92:102097. doi: 10.1016/j.molmet.2025.102097. Online ahead of print. Mol Metab. 2025. PMID: 39788290 Free article.

4

NRF2 Dysregulation in Mice Leads to Inadequate Beta-Cell Mass Expansion during Pregnancy and Gestational Diabetes.

Baumel-Alterzon S, Tse I, Heidery F, Garcia-Ocaña A, Scott DK. Baumel-Alterzon S, et al. bioRxiv [Preprint]. 2023 Aug 28:2023.08.28.555207. doi: 10.1101/2023.08.28.555207. bioRxiv. 2023. PMID: 37693560 Free PMC article. Preprint.

5

NRF2 is required for neonatal mouse beta cell growth by maintaining redox balance and promoting mitochondrial biogenesis and function.

Baumel-Alterzon S, Katz LS, Lambertini L, Tse I, Heidery F, Garcia-Ocaña A, Scott DK. Baumel-Alterzon S, et al. Among authors: garcia ocana a. Diabetologia. 2024 Mar;67(3):547-560. doi: 10.1007/s00125-023-06071-7. Epub 2024 Jan 11. Diabetologia. 2024. PMID: 38206362 Free PMC article.

6

Cycling alpha cells in regenerative drug-treated human pancreatic islets may serve as key beta cell progenitors.

Karakose E, Wang X, Wang P, Carcamo S, Demircioglu D, Lambertini L, Wood O, Kang R, Lu G, Scott DK, Garcia-Ocaña A, Argmann C, Sebra RP, Hasson D, Stewart AF. Karakose E, et al. Among authors: garcia ocana a. Cell Rep Med. 2024 Dec 17;5(12):101832. doi: 10.1016/j.xcrm.2024.101832. Epub 2024 Dec 2. Cell Rep Med. 2024. PMID: 39626675 Free PMC article.

7

A Phase 1 single ascending dose study of pure oral harmine in healthy volunteers.

Ables JL, Israel L, Wood O, Govindarajulu U, Fremont RT, Banerjee R, Liu H, Cohen J, Wang P, Kumar K, Lu G, DeVita RJ, Garcia-Ocaña A, Murrough JW, Stewart AF. Ables JL, et al. Among authors: garcia ocana a. J Psychopharmacol. 2024 Oct;38(10):911-923. doi: 10.1177/02698811241273772. Epub 2024 Sep 20. J Psychopharmacol. 2024. PMID: 39301926 Free PMC article. Clinical Trial.

8

Editorial: Progression to Diabetes: Molecular and cellular mechanisms.

Guillén C, Garcia-Ocana A. Guillén C, et al. Front Endocrinol (Lausanne). 2023 Feb 7;14:1141337. doi: 10.3389/fendo.2023.1141337. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36824361 Free PMC article. No abstract available.

9

Acute inhibition of iron-sulfur cluster biosynthesis disrupts metabolic flexibility in mice.

Molenaars M, Mir H, Alvarez SW, Arivazhagan L, Rosselot C, Zhan D, Park CY, Garcia-Ocana A, Schmidt AM, Possemato R. Molenaars M, et al. Among authors: garcia ocana a. bioRxiv [Preprint]. 2024 Aug 19:2024.08.19.608291. doi: 10.1101/2024.08.19.608291. bioRxiv. 2024. PMID: 39229169 Free PMC article. Preprint.

10

Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system.

Rosselot C, Li Y, Wang P, Alvarsson A, Beliard K, Lu G, Kang R, Li R, Liu H, Gillespie V, Tzavaras N, Kumar K, DeVita RJ, Stewart AF, Stanley SA, Garcia-Ocaña A. Rosselot C, et al. Among authors: garcia ocana a. Sci Transl Med. 2024 Jul 10;16(755):eadg3456. doi: 10.1126/scitranslmed.adg3456. Epub 2024 Jul 10. Sci Transl Med. 2024. PMID: 38985854

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