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Addressing the dNTP bottleneck restricting prime editing activity.
Ponnienselvan K, Liu P, Nyalile T, Oikemus S, Joynt AT, Kelly K, Guo D, Chen Z, Lee JM, Schiffer CA, Emerson CP, Lawson ND, Watts JK, Sontheimer EJ, Luban J, Wolfe SA. Ponnienselvan K, et al. Among authors: lee jm. bioRxiv [Preprint]. 2023 Oct 29:2023.10.21.563443. doi: 10.1101/2023.10.21.563443. bioRxiv. 2023. PMID: 37904991 Free PMC article. Preprint.
Direct delivery of stabilized Cas-embedded base editors achieves efficient and accurate editing of clinically relevant targets.
Lee JM, Zeng J, Liu P, Nguyen MA, Loustaunau DS, Bauer DE, Yilmaz NK, Wolfe SA, Schiffer CA. Lee JM, et al. bioRxiv [Preprint]. 2024 Feb 8:2024.02.08.579528. doi: 10.1101/2024.02.08.579528. bioRxiv. 2024. Update in: Nucleic Acids Res. 2025 Jan 7;53(1):gkae1217. doi: 10.1093/nar/gkae1217 PMID: 38370706 Free PMC article. Updated. Preprint.
Increasing intracellular dNTP levels improves prime editing efficiency.
Liu P, Ponnienselvan K, Nyalile T, Oikemus S, Joynt AT, Iyer S, Kelly K, Guo D, Kyawe PP, Vanderleeden E, Redick SD, Huang L, Chen Z, Lee JM, Schiffer CA, Harlan DM, Wang JP, Emerson CP Jr, Lawson ND, Watts JK, Sontheimer EJ, Luban J, Wolfe SA. Liu P, et al. Among authors: lee jm. Nat Biotechnol. 2024 Sep 25. doi: 10.1038/s41587-024-02405-x. Online ahead of print. Nat Biotechnol. 2024. PMID: 39322763
7,168 results