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LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase.
Ferrarone JR, Thomas J, Unni AM, Zheng Y, Nagiec MJ, Gardner EE, Mashadova O, Li K, Koundouros N, Montalbano A, Mustafa M, Cantley LC, Blenis J, Sanjana NE, Varmus H. Ferrarone JR, et al. Among authors: sanjana ne. bioRxiv [Preprint]. 2023 Oct 20:2023.10.19.563158. doi: 10.1101/2023.10.19.563158. bioRxiv. 2023. PMID: 37904985 Free PMC article. Preprint.
Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus.
Kasela S, Daniloski Z, Jordan TX, tenOever BR, Sanjana NE, Lappalainen T. Kasela S, et al. Among authors: sanjana ne. medRxiv [Preprint]. 2021 Apr 13:2021.04.09.21255184. doi: 10.1101/2021.04.09.21255184. medRxiv. 2021. Update in: Genome Biol. 2021 Aug 23;22(1):242. doi: 10.1186/s13059-021-02454-4 PMID: 33880488 Free PMC article. Updated. Preprint.
Paired CRISPR screens to map gene regulation in cis and trans.
Xue X, Gajic ZZ, Caragine CM, Legut M, Walker C, Kim JYS, Wang X, Yan RE, Wessels HH, Lu C, Bapodra N, Gürsoy G, Sanjana NE. Xue X, et al. Among authors: sanjana ne. bioRxiv [Preprint]. 2024 Nov 27:2024.11.27.625752. doi: 10.1101/2024.11.27.625752. bioRxiv. 2024. PMID: 39651170 Free PMC article. Preprint.
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes.
Megagiannis P, Mei Y, Yan RE, Yuan L, Wilde JJ, Eckersberg H, Suresh R, Tan X, Chen H, Farmer WT, Cha K, Le PU, Catoire H, Rochefort D, Kwan T, Yee BA, Dion P, Krishnaswamy A, Cloutier JF, Stifani S, Petrecca K, Yeo GW, Murai KK, Feng G, Rouleau GA, Ideker T, Sanjana NE, Zhou Y. Megagiannis P, et al. Among authors: sanjana ne. Cell Rep. 2024 Aug 27;43(8):114637. doi: 10.1016/j.celrep.2024.114637. Epub 2024 Aug 17. Cell Rep. 2024. PMID: 39154337 Free article.
Low copy CRISPR-Cas13d mitigates collateral RNA cleavage.
Hart SK, Wessels HH, Méndez-Mancilla A, Müller S, Drabavicius G, Choi O, Sanjana NE. Hart SK, et al. Among authors: sanjana ne. bioRxiv [Preprint]. 2024 May 14:2024.05.13.594039. doi: 10.1101/2024.05.13.594039. bioRxiv. 2024. PMID: 38798586 Free PMC article. Preprint.
79 results