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Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization.
Meng Y, Garnish SE, Davies KA, Black KA, Leis AP, Horne CR, Hildebrand JM, Hoblos H, Fitzgibbon C, Young SN, Dite T, Dagley LF, Venkat A, Kannan N, Koide A, Koide S, Glukhova A, Czabotar PE, Murphy JM. Meng Y, et al. Among authors: kannan n. Nat Commun. 2023 Oct 26;14(1):6804. doi: 10.1038/s41467-023-42255-w. Nat Commun. 2023. PMID: 37884510 Free PMC article.
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.
Davies KA, Fitzgibbon C, Young SN, Garnish SE, Yeung W, Coursier D, Birkinshaw RW, Sandow JJ, Lehmann WIL, Liang LY, Lucet IS, Chalmers JD, Patrick WM, Kannan N, Petrie EJ, Czabotar PE, Murphy JM. Davies KA, et al. Among authors: kannan n. Nat Commun. 2020 Jun 19;11(1):3060. doi: 10.1038/s41467-020-16823-3. Nat Commun. 2020. PMID: 32561735 Free PMC article.
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.
Garnish SE, Meng Y, Koide A, Sandow JJ, Denbaum E, Jacobsen AV, Yeung W, Samson AL, Horne CR, Fitzgibbon C, Young SN, Smith PPC, Webb AI, Petrie EJ, Hildebrand JM, Kannan N, Czabotar PE, Koide S, Murphy JM. Garnish SE, et al. Among authors: kannan n. Nat Commun. 2021 Apr 13;12(1):2211. doi: 10.1038/s41467-021-22400-z. Nat Commun. 2021. PMID: 33850121 Free PMC article.
479 results