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Page 1
Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.
Ohta A, Tanada M, Shinohara S, Morita Y, Nakano K, Yamagishi Y, Takano R, Kariyuki S, Iida T, Matsuo A, Ozeki K, Emura T, Sakurai Y, Takano K, Higashida A, Kojima M, Muraoka T, Takeyama R, Kato T, Kimura K, Ogawa K, Ohara K, Tanaka S, Kikuchi Y, Hisada N, Hayashi R, Nishimura Y, Nomura K, Tachibana T, Irie M, Kawada H, Torizawa T, Murao N, Kotake T, Tanaka M, Ishikawa S, Miyake T, Tamiya M, Arai M, Chiyoda A, Akai S, Sase H, Kuramoto S, Ito T, Shiraishi T, Kojima T, Iikura H. Ohta A, et al. Among authors: irie m. J Am Chem Soc. 2023 Nov 8;145(44):24035-24051. doi: 10.1021/jacs.3c07145. Epub 2023 Oct 24. J Am Chem Soc. 2023. PMID: 37874670
Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor.
Tanada M, Tamiya M, Matsuo A, Chiyoda A, Takano K, Ito T, Irie M, Kotake T, Takeyama R, Kawada H, Hayashi R, Ishikawa S, Nomura K, Furuichi N, Morita Y, Kage M, Hashimoto S, Nii K, Sase H, Ohara K, Ohta A, Kuramoto S, Nishimura Y, Iikura H, Shiraishi T. Tanada M, et al. Among authors: irie m. J Am Chem Soc. 2023 Aug 2;145(30):16610-16620. doi: 10.1021/jacs.3c03886. Epub 2023 Jul 18. J Am Chem Soc. 2023. PMID: 37463267
Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease.
Okura Y, Ikawa-Teranishi Y, Mizoroki A, Takahashi N, Tsushima T, Irie M, Harfuddin Z, Miura-Okuda M, Ito S, Nakamura G, Takesue H, Ozono Y, Nishihara M, Yamada K, Gan SW, Hayasaka A, Ishii S, Wakabayashi T, Muraoka M, Nagaya N, Hino H, Nemoto T, Kuramochi T, Torizawa T, Shimada H, Kitazawa T, Okazaki M, Nezu J, Sollid LM, Igawa T. Okura Y, et al. Among authors: irie m. Nat Commun. 2023 Dec 22;14(1):8502. doi: 10.1038/s41467-023-44083-4. Nat Commun. 2023. PMID: 38135691 Free PMC article.
Structure-activity relationships of middle-size cyclic peptides, KRAS inhibitors derived from an mRNA display.
Kage M, Hayashi R, Matsuo A, Tamiya M, Kuramoto S, Ohara K, Irie M, Chiyoda A, Takano K, Ito T, Kotake T, Takeyama R, Ishikawa S, Nomura K, Furuichi N, Morita Y, Hashimoto S, Kawada H, Nishimura Y, Nii K, Sase H, Ohta A, Kojima T, Iikura H, Tanada M, Shiraishi T. Kage M, et al. Among authors: irie m. Bioorg Med Chem. 2024 Aug 1;110:117830. doi: 10.1016/j.bmc.2024.117830. Epub 2024 Jul 6. Bioorg Med Chem. 2024. PMID: 38981216
Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases.
Fukuzawa T, Sampei Z, Haraya K, Ruike Y, Shida-Kawazoe M, Shimizu Y, Gan SW, Irie M, Tsuboi Y, Tai H, Sakiyama T, Sakamoto A, Ishii S, Maeda A, Iwayanagi Y, Shibahara N, Shibuya M, Nakamura G, Nambu T, Hayasaka A, Mimoto F, Okura Y, Hori Y, Habu K, Wada M, Miura T, Tachibana T, Honda K, Tsunoda H, Kitazawa T, Kawabe Y, Igawa T, Hattori K, Nezu J. Fukuzawa T, et al. Among authors: irie m. Sci Rep. 2017 Apr 24;7(1):1080. doi: 10.1038/s41598-017-01087-7. Sci Rep. 2017. PMID: 28439081 Free PMC article.
A multicountry evaluation of the Xpert MTB/RIF assay for the diagnosis of intrathoracic tuberculosis in children using alternative specimens (nasopharyngeal aspirate and stool): A prospective cohort study conducted in Madagascar, Ivory Coast and Cameroon (TB Kids project).
Randremanana RV, Tejiokem M, Rakotosamimanana N, Donfack VD, Mbouchong VB, Randrianarisoa M, Harimanana A, Taguebue JV, Ndiang ST, Itchy V, Robinson A, Ravelomanana L, Rakotomahefa M, Ranoharison D, Soumahoro MK, Gicquel B, N'Guessan R, Eyangoh S, Rasolofo V; TB-KIDS Study group.The authors + Emery Flavien Akpafi; Irie MIB, Bai-Orsot A, Septoh JFY, Abogo S, Raherison MS, Rakotoson A, Raharimanga V, Piola P, Ranaivomanana P, Collard JM, Andrianah GPE, Razafindranaivo T, Mangahasimbola RT, Victoir K. Randremanana RV, et al. Among authors: irie mib. Int J Infect Dis. 2024 Dec 16:107366. doi: 10.1016/j.ijid.2024.107366. Online ahead of print. Int J Infect Dis. 2024. PMID: 39694229 Free article.
Effectiveness of benralizumab in the Tokyo Asthma Study (TOAST): A real-world prospective interventional trial.
Masaki K, Suzukawa M, Sasano H, Harada N, Miyazaki Y, Katsura H, Tagaya E, Terada J, Hojo M, Sugimoto N, Nagase H, Kono Y, Hiranuma H, Gon Y, Takemura R, Irie M, Nakamura R, Kabata H, Miyata J, Fukunaga K. Masaki K, et al. Among authors: irie m. Allergol Int. 2024 Dec 3:S1323-8930(24)00128-X. doi: 10.1016/j.alit.2024.10.009. Online ahead of print. Allergol Int. 2024. PMID: 39632158 Free article.
894 results