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Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors.
Castiglioni A, Yang Y, Williams K, Gogineni A, Lane RS, Wang AW, Shyer JA, Zhang Z, Mittman S, Gutierrez A, Astarita JL, Thai M, Hung J, Yang YA, Pourmohamad T, Himmels P, De Simone M, Elstrott J, Capietto AH, Cubas R, Modrusan Z, Sandoval W, Ziai J, Gould SE, Fu W, Wang Y, Koerber JT, Sanjabi S, Mellman I, Turley SJ, Müller S. Castiglioni A, et al. Among authors: shyer ja. Nat Commun. 2023 Aug 5;14(1):4703. doi: 10.1038/s41467-023-40398-4. Nat Commun. 2023. PMID: 37543621 Free PMC article.
IL-4 Licenses B Cell Activation Through Cholesterol Synthesis.
Steach HR, York AG, Skadow MH, Chen S, Zhao J, Williams KJ, Zhou Q, Hsieh WY, Brewer JR, Qu R, Shyer JA, Harman C, Sefik E, Mowell WK, Bailis W, Cui C, Kluger Y, Bensinger SJ, Craft J, Flavell RA. Steach HR, et al. Among authors: shyer ja. bioRxiv [Preprint]. 2024 May 15:2024.05.13.593964. doi: 10.1101/2024.05.13.593964. bioRxiv. 2024. PMID: 38798553 Free PMC article. Preprint.
LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity.
Krishnamurty AT, Shyer JA, Thai M, Gandham V, Buechler MB, Yang YA, Pradhan RN, Wang AW, Sanchez PL, Qu Y, Breart B, Chalouni C, Dunlap D, Ziai J, Elstrott J, Zacharias N, Mao W, Rowntree RK, Sadowsky J, Lewis GD, Pillow TH, Nabet BY, Banchereau R, Tam L, Caothien R, Bacarro N, Roose-Girma M, Modrusan Z, Mariathasan S, Müller S, Turley SJ. Krishnamurty AT, et al. Among authors: shyer ja. Nature. 2022 Nov;611(7934):148-154. doi: 10.1038/s41586-022-05272-1. Epub 2022 Sep 28. Nature. 2022. PMID: 36171287 Free PMC article.
An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis.
Harman CCD, Bailis W, Zhao J, Hill L, Qu R, Jackson RP, Shyer JA, Steach HR, Kluger Y, Goff LA, Rinn JL, Williams A, Henao-Mejia J, Flavell RA. Harman CCD, et al. Among authors: shyer ja. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e1918062118. doi: 10.1073/pnas.1918062118. Proc Natl Acad Sci U S A. 2021. PMID: 33446502 Free PMC article.
Metabolic signaling in T cells.
Shyer JA, Flavell RA, Bailis W. Shyer JA, et al. Cell Res. 2020 Aug;30(8):649-659. doi: 10.1038/s41422-020-0379-5. Epub 2020 Jul 24. Cell Res. 2020. PMID: 32709897 Free PMC article. Review.
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