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Aryne-Enabled C-N Arylation of Anilines.
Sephton T, Charitou A, Trujillo C, Large JM, Butterworth S, Greaney MF. Sephton T, et al. Among authors: large jm. Angew Chem Int Ed Engl. 2023 Dec 4;62(49):e202310583. doi: 10.1002/anie.202310583. Epub 2023 Nov 6. Angew Chem Int Ed Engl. 2023. PMID: 37850515 Free PMC article.
XAT-Catalysis for Intramolecular Biaryl Synthesis.
Sephton T, Large JM, Natrajan LS, Butterworth S, Greaney MF. Sephton T, et al. Among authors: large jm. Angew Chem Int Ed Engl. 2024 Aug 26;63(35):e202407979. doi: 10.1002/anie.202407979. Epub 2024 Jul 17. Angew Chem Int Ed Engl. 2024. PMID: 38818676
Diarylamine Synthesis via Desulfinylative Smiles Rearrangement.
Sephton T, Large JM, Butterworth S, Greaney MF. Sephton T, et al. Among authors: large jm. Org Lett. 2022 Feb 11;24(5):1132-1135. doi: 10.1021/acs.orglett.1c04122. Epub 2022 Jan 30. Org Lett. 2022. PMID: 35094513 Free PMC article.
Aprepitant is a novel, selective activator of the K2P channel TRAAK.
McCoull D, Veale EL, Walsh Y, Byrom L, Avkiran T, Large JM, Vaitone E, Gaffey F, Jerman J, Mathie A, Wright PD. McCoull D, et al. Among authors: large jm. Biochem Biophys Res Commun. 2022 Jan 15;588:41-46. doi: 10.1016/j.bbrc.2021.12.031. Epub 2021 Dec 14. Biochem Biophys Res Commun. 2022. PMID: 34942533 Free article.
Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.
Large JM, Birchall K, Bouloc NS, Merritt AT, Smiljanic-Hurley E, Tsagris DJ, Wheldon MC, Ansell KH, Coombs PJ, Kettleborough CA, Whalley D, Stewart LB, Bowyer PW, Baker DA, Osborne SA. Large JM, et al. Bioorg Med Chem Lett. 2019 Oct 1;29(19):126610. doi: 10.1016/j.bmcl.2019.08.014. Epub 2019 Aug 9. Bioorg Med Chem Lett. 2019. PMID: 31471167 Free PMC article.
28 results