Gu X - Search Results

1

Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease.

Wilton DK, Mastro K, Heller MD, Gergits FW, Willing CR, Fahey JB, Frouin A, Daggett A, Gu X, Kim YA, Faull RLM, Jayadev S, Yednock T, Yang XW, Stevens B. Wilton DK, et al. Among authors: gu x. Nat Med. 2023 Nov;29(11):2866-2884. doi: 10.1038/s41591-023-02566-3. Epub 2023 Oct 9. Nat Med. 2023. PMID: 37814059 Free PMC article.

2

Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.

Gu X, Li C, Wei W, Lo V, Gong S, Li SH, Iwasato T, Itohara S, Li XJ, Mody I, Heintz N, Yang XW. Gu X, et al. Neuron. 2005 May 5;46(3):433-44. doi: 10.1016/j.neuron.2005.03.025. Neuron. 2005. PMID: 15882643 Free article.

3

Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease.

Gu X, André VM, Cepeda C, Li SH, Li XJ, Levine MS, Yang XW. Gu X, et al. Mol Neurodegener. 2007 Apr 30;2:8. doi: 10.1186/1750-1326-2-8. Mol Neurodegener. 2007. PMID: 17470275 Free PMC article.

4

Progressive synaptic pathology of motor cortical neurons in a BAC transgenic mouse model of Huntington's disease.

Spampanato J, Gu X, Yang XW, Mody I. Spampanato J, et al. Among authors: gu x. Neuroscience. 2008 Dec 2;157(3):606-20. doi: 10.1016/j.neuroscience.2008.09.020. Epub 2008 Sep 18. Neuroscience. 2008. PMID: 18854207 Free PMC article.

5

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.

Gu X, Greiner ER, Mishra R, Kodali R, Osmand A, Finkbeiner S, Steffan JS, Thompson LM, Wetzel R, Yang XW. Gu X, et al. Neuron. 2009 Dec 24;64(6):828-40. doi: 10.1016/j.neuron.2009.11.020. Neuron. 2009. PMID: 20064390 Free PMC article.

6

An antisense CAG repeat transcript at JPH3 locus mediates expanded polyglutamine protein toxicity in Huntington's disease-like 2 mice.

Wilburn B, Rudnicki DD, Zhao J, Weitz TM, Cheng Y, Gu X, Greiner E, Park CS, Wang N, Sopher BL, La Spada AR, Osmand A, Margolis RL, Sun YE, Yang XW. Wilburn B, et al. Among authors: gu x. Neuron. 2011 May 12;70(3):427-40. doi: 10.1016/j.neuron.2011.03.021. Neuron. 2011. PMID: 21555070 Free PMC article.

7

A novel BACHD transgenic rat exhibits characteristic neuropathological features of Huntington disease.

Yu-Taeger L, Petrasch-Parwez E, Osmand AP, Redensek A, Metzger S, Clemens LE, Park L, Howland D, Calaminus C, Gu X, Pichler B, Yang XW, Riess O, Nguyen HP. Yu-Taeger L, et al. Among authors: gu x. J Neurosci. 2012 Oct 31;32(44):15426-38. doi: 10.1523/JNEUROSCI.1148-12.2012. J Neurosci. 2012. PMID: 23115180 Free PMC article.

8

Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.

Wang N, Gray M, Lu XH, Cantle JP, Holley SM, Greiner E, Gu X, Shirasaki D, Cepeda C, Li Y, Dong H, Levine MS, Yang XW. Wang N, et al. Among authors: gu x. Nat Med. 2014 May;20(5):536-41. doi: 10.1038/nm.3514. Epub 2014 Apr 28. Nat Med. 2014. PMID: 24784230 Free PMC article.

9

N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice.

Gu X, Cantle JP, Greiner ER, Lee CY, Barth AM, Gao F, Park CS, Zhang Z, Sandoval-Miller S, Zhang RL, Diamond M, Mody I, Coppola G, Yang XW. Gu X, et al. Neuron. 2015 Feb 18;85(4):726-41. doi: 10.1016/j.neuron.2015.01.008. Epub 2015 Feb 5. Neuron. 2015. PMID: 25661181 Free PMC article.

10

The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington's disease model.

Veldman MB, Rios-Galdamez Y, Lu XH, Gu X, Qin W, Li S, Yang XW, Lin S. Veldman MB, et al. Among authors: gu x. Mol Neurodegener. 2015 Dec 9;10:67. doi: 10.1186/s13024-015-0063-2. Mol Neurodegener. 2015. PMID: 26645399 Free PMC article.

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