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CD8 + T-cell priming is quantitatively but not qualitatively impaired in people with HIV-1 on antiretroviral therapy.
Cabral-Piccin MP, Briceño O, Papagno L, Liouville B, White E, Perdomo-Celis F, Autaa G, Volant S, Llewellyn-Lacey S, Fromentin R, Chomont N, Price DA, Sáez-Cirión A, Lambotte O, Katlama C, Appay V. Cabral-Piccin MP, et al. Among authors: llewellyn lacey s. AIDS. 2024 Feb 1;38(2):161-166. doi: 10.1097/QAD.0000000000003746. Epub 2023 Oct 5. AIDS. 2024. PMID: 37800637
Peptide length determines the outcome of TCR/peptide-MHCI engagement.
Ekeruche-Makinde J, Miles JJ, van den Berg HA, Skowera A, Cole DK, Dolton G, Schauenburg AJ, Tan MP, Pentier JM, Llewellyn-Lacey S, Miles KM, Bulek AM, Clement M, Williams T, Trimby A, Bailey M, Rizkallah P, Rossjohn J, Peakman M, Price DA, Burrows SR, Sewell AK, Wooldridge L. Ekeruche-Makinde J, et al. Blood. 2013 Feb 14;121(7):1112-23. doi: 10.1182/blood-2012-06-437202. Epub 2012 Dec 18. Blood. 2013. PMID: 23255554 Free PMC article.
CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.
Dockree T, Holland CJ, Clement M, Ladell K, McLaren JE, van den Berg HA, Gostick E, L Miners K, Llewellyn-Lacey S, Bridgeman JS, Man S, Bailey M, Burrows SR, Price DA, Wooldridge L. Dockree T, et al. Immunol Cell Biol. 2017 Jan;95(1):68-76. doi: 10.1038/icb.2016.85. Epub 2016 Nov 8. Immunol Cell Biol. 2017. PMID: 27670790 Free PMC article.
Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load.
Schuch A, Salimi Alizei E, Heim K, Wieland D, Kiraithe MM, Kemming J, Llewellyn-Lacey S, Sogukpinar Ö, Ni Y, Urban S, Zimmermann P, Nassal M, Emmerich F, Price DA, Bengsch B, Luxenburger H, Neumann-Haefelin C, Hofmann M, Thimme R. Schuch A, et al. Gut. 2019 May;68(5):905-915. doi: 10.1136/gutjnl-2018-316641. Epub 2019 Jan 8. Gut. 2019. PMID: 30622109 Free article.
TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells.
Sekine T, Perez-Potti A, Nguyen S, Gorin JB, Wu VH, Gostick E, Llewellyn-Lacey S, Hammer Q, Falck-Jones S, Vangeti S, Yu M, Smed-Sörensen A, Gaballa A, Uhlin M, Sandberg JK, Brander C, Nowak P, Goepfert PA, Price DA, Betts MR, Buggert M. Sekine T, et al. Sci Immunol. 2020 Jul 3;5(49):eaba7918. doi: 10.1126/sciimmunol.aba7918. Sci Immunol. 2020. PMID: 32620560
Optimal Maturation of the SIV-Specific CD8+ T Cell Response after Primary Infection Is Associated with Natural Control of SIV: ANRS SIC Study.
Passaes C, Millet A, Madelain V, Monceaux V, David A, Versmisse P, Sylla N, Gostick E, Llewellyn-Lacey S, Price DA, Blancher A, Dereuddre-Bosquet N, Desjardins D, Pancino G, Le Grand R, Lambotte O, Müller-Trutwin M, Rouzioux C, Guedj J, Avettand-Fenoel V, Vaslin B, Sáez-Cirión A. Passaes C, et al. Cell Rep. 2020 Sep 22;32(12):108174. doi: 10.1016/j.celrep.2020.108174. Cell Rep. 2020. PMID: 32966788 Free article.
TOX defines the degree of CD8+ T cell dysfunction in distinct phases of chronic HBV infection.
Heim K, Binder B, Sagar, Wieland D, Hensel N, Llewellyn-Lacey S, Gostick E, Price DA, Emmerich F, Vingerhoet H, Kraft ARM, Cornberg M, Boettler T, Neumann-Haefelin C, Zehn D, Bengsch B, Hofmann M, Thimme R. Heim K, et al. Gut. 2020 Oct 23;70(8):1550-60. doi: 10.1136/gutjnl-2020-322404. Online ahead of print. Gut. 2020. PMID: 33097558 Free PMC article.
Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection.
Hensel N, Gu Z, Sagar, Wieland D, Jechow K, Kemming J, Llewellyn-Lacey S, Gostick E, Sogukpinar O, Emmerich F, Price DA, Bengsch B, Boettler T, Neumann-Haefelin C, Eils R, Conrad C, Bartenschlager R, Grün D, Ishaque N, Thimme R, Hofmann M. Hensel N, et al. Nat Immunol. 2021 Feb;22(2):229-239. doi: 10.1038/s41590-020-00817-w. Epub 2021 Jan 4. Nat Immunol. 2021. PMID: 33398179
44 results