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Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice.
Marques PE, Oliveira AG, Pereira RV, David BA, Gomides LF, Saraiva AM, Pires DA, Novaes JT, Patricio DO, Cisalpino D, Menezes-Garcia Z, Leevy WM, Chapman SE, Mahecha G, Marques RE, Guabiraba R, Martins VP, Souza DG, Mansur DS, Teixeira MM, Leite MF, Menezes GB. Marques PE, et al. Among authors: mansur ds. Hepatology. 2015 Jan;61(1):348-60. doi: 10.1002/hep.27216. Epub 2014 Jul 31. Hepatology. 2015. PMID: 24824608
An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans.
Delgobo M, Mendes DA, Kozlova E, Rocha EL, Rodrigues-Luiz GF, Mascarin L, Dias G, Patrício DO, Dierckx T, Bicca MA, Bretton G, Tenório de Menezes YK, Starick MR, Rovaris D, Del Moral J, Mansur DS, Van Weyenbergh J, Báfica A. Delgobo M, et al. Among authors: mansur ds. Elife. 2019 Oct 22;8:e47013. doi: 10.7554/eLife.47013. Elife. 2019. PMID: 31637998 Free PMC article.
Neuraminidase inhibitors rewire neutrophil function in vivo in murine sepsis and ex vivo in COVID-19.
de Oliveira Formiga R, Amaral FC, Souza CF, Mendes DAGB, Wanderley CWS, Lorenzini CB, Santos AA, Antônia J, Faria LF, Natale CC, Paula NM, Silva PCS, Fonseca FR, Aires L, Heck N, Starick MR, Queiroz-Junior CM, Santos FRS, de Souza FRO, Costa VV, Barroso SPC, Morrot A, Van Weyenbergh J, Sordi R, Alisson-Silva F, Cunha FQ, Rocha EL, Chollet-Martin S, Hurtado-Nedelec MM, Martin C, Burgel PR, Mansur DS, Maurici R, Macauley MS, Báfica A, Witko-Sarsat V, Spiller F. de Oliveira Formiga R, et al. Among authors: mansur ds. bioRxiv [Preprint]. 2022 Oct 14:2020.11.12.379115. doi: 10.1101/2020.11.12.379115. bioRxiv. 2022. PMID: 33200130 Free PMC article. Preprint.
Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19.
de Oliveira Formiga R, Amaral FC, Souza CF, Mendes DAGB, Wanderley CWS, Lorenzini CB, Santos AA, Antônia J, Faria LF, Natale CC, Paula NM, Silva PCS, Fonseca FR, Aires L, Heck N, Starick MR, Queiroz-Junior CM, Santos FRS, de Souza FRO, Costa VV, Barroso SPC, Morrot A, Van Weyenbergh J, Sordi R, Alisson-Silva F, Cunha FQ, Rocha EL, Chollet-Martin S, Hurtado-Nedelec MM, Martin C, Burgel PR, Mansur DS, Maurici R, Macauley MS, Báfica A, Witko-Sarsat V, Spiller F. de Oliveira Formiga R, et al. Among authors: mansur ds. Br J Pharmacol. 2023 Jun;180(11):1460-1481. doi: 10.1111/bph.16013. Epub 2023 Jan 13. Br J Pharmacol. 2023. PMID: 36526272 Free PMC article.
ISG15/USP18/STAT2 is a molecular hub regulating IFN I-mediated control of Dengue and Zika virus replication.
Espada CE, da Rocha EL, Ricciardi-Jorge T, Dos Santos AA, Soares ZG, Malaquias G, Patrício DO, Gonzalez Kozlova E, Dos Santos PF, Bordignon J, Sanford TJ, Fajardo T, Sweeney TR, Báfica A, Mansur DS. Espada CE, et al. Among authors: mansur ds. Front Immunol. 2024 Feb 7;15:1331731. doi: 10.3389/fimmu.2024.1331731. eCollection 2024. Front Immunol. 2024. PMID: 38384473 Free PMC article.
Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response.
Antunes KH, Fachi JL, de Paula R, da Silva EF, Pral LP, Dos Santos AÁ, Dias GBM, Vargas JE, Puga R, Mayer FQ, Maito F, Zárate-Bladés CR, Ajami NJ, Sant'Ana MR, Candreva T, Rodrigues HG, Schmiele M, Silva Clerici MTP, Proença-Modena JL, Vieira AT, Mackay CR, Mansur D, Caballero MT, Marzec J, Li J, Wang X, Bell D, Polack FP, Kleeberger SR, Stein RT, Vinolo MAR, de Souza APD. Antunes KH, et al. Nat Commun. 2019 Jul 22;10(1):3273. doi: 10.1038/s41467-019-11152-6. Nat Commun. 2019. PMID: 31332169 Free PMC article.
46 results