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Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice.
Chen SY, Beretta M, Olzomer EM, Alexopoulos SJ, Shah DP, Byrne FL, Salamoun JM, Garcia CJ, Smith GC, Larance M, Philp A, Turner N, Santos WL, Cantley J, Hoehn KL. Chen SY, et al. Among authors: santos wl. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166908. doi: 10.1016/j.bbadis.2023.166908. Epub 2023 Oct 2. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 37793464 Free PMC article.
Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.
Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL. Kenwood BM, et al. Among authors: santos wl. Mol Metab. 2013 Nov 28;3(2):114-23. doi: 10.1016/j.molmet.2013.11.005. eCollection 2014 Apr. Mol Metab. 2013. PMID: 24634817 Free PMC article.
Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress.
Byrne FL, Olzomer EM, Marriott GR, Quek LE, Katen A, Su J, Nelson ME, Hart-Smith G, Larance M, Sebesfi VF, Cuff J, Martyn GE, Childress E, Alexopoulos SJ, Poon IK, Faux MC, Burgess AW, Reid G, McCarroll JA, Santos WL, Quinlan KG, Turner N, Fazakerley DJ, Kumar N, Hoehn KL. Byrne FL, et al. Among authors: santos wl. Redox Biol. 2020 Jan;28:101374. doi: 10.1016/j.redox.2019.101374. Epub 2019 Nov 5. Redox Biol. 2020. PMID: 31743887 Free PMC article.
[1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis.
Childress ES, Salamoun JM, Hargett SR, Alexopoulos SJ, Chen SY, Shah DP, Santiago-Rivera J, Garcia CJ, Dai Y, Tucker SP, Hoehn KL, Santos WL. Childress ES, et al. Among authors: santos wl. J Med Chem. 2020 Mar 12;63(5):2511-2526. doi: 10.1021/acs.jmedchem.9b01440. Epub 2020 Feb 17. J Med Chem. 2020. PMID: 32017849 Free PMC article.
Anilinopyrazines as potential mitochondrial uncouplers.
Murray JH, Hargett S, Hoehn KL, Santos WL. Murray JH, et al. Among authors: santos wl. Bioorg Med Chem Lett. 2020 Apr 15;30(8):127057. doi: 10.1016/j.bmcl.2020.127057. Epub 2020 Feb 21. Bioorg Med Chem Lett. 2020. PMID: 32113842
6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis.
Salamoun JM, Garcia CJ, Hargett SR, Murray JH, Chen SY, Beretta M, Alexopoulos SJ, Shah DP, Olzomer EM, Tucker SP, Hoehn KL, Santos WL. Salamoun JM, et al. Among authors: santos wl. J Med Chem. 2020 Jun 11;63(11):6203-6224. doi: 10.1021/acs.jmedchem.0c00542. Epub 2020 May 27. J Med Chem. 2020. PMID: 32392051 Free PMC article.
Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice.
Alexopoulos SJ, Chen SY, Brandon AE, Salamoun JM, Byrne FL, Garcia CJ, Beretta M, Olzomer EM, Shah DP, Philp AM, Hargett SR, Lawrence RT, Lee B, Sligar J, Carrive P, Tucker SP, Philp A, Lackner C, Turner N, Cooney GJ, Santos WL, Hoehn KL. Alexopoulos SJ, et al. Among authors: santos wl. Nat Commun. 2020 May 14;11(1):2397. doi: 10.1038/s41467-020-16298-2. Nat Commun. 2020. PMID: 32409697 Free PMC article.
222 results